Trallero, GloriaCasas Flecha, InmaculadaTenorio, AntonioEchevarria, Juan EmilioCastellanos-Nadal, Ana MariaLozano, AlvaroPerez-Breña, Pilar2020-12-142020-12-142000-06Epidemiol Infect 2000 Jun;124(3):497-506.http://hdl.handle.net/20.500.12105/11524A total of 15,662 clinical samples were analysed for enterovirus (EV) isolation in cell cultures during a 10-year period (1988-97). Furthermore, 210 isolates of EV obtained in primary laboratories within Spain from patients with meningitis were characterized. The total number of EV typed was 758, including 727 non-polio EV and 31 Sabin-like (SL) polioviruses. Twenty-eight EV serotypes were represented. Echoviruses comprised 90% (653/727) of fully typed non-polio EV. The four most prevalent serotypes were echovirus 30, echovirus 9, echovirus 6 and echovirus 4. Echovirus 30 was the main serotype associated with meningitis. Echovirus 9 was the aetiological agent in 20 outbreaks of meningitis while the occurrence of echovirus 6 was localized in 1 year (1997). Coxsackieviruses A and B occurred in 3 and 7% of the non-polio EV respectively. Coxsackievirus B5 presented the relative greater abundance. This paper examines the epidemiology of EV in Spain to serotype level over a 10-year period with special attention to non-polio EV associated with meningitis.engVoRDisease OutbreaksAdolescentAdultAgedChildChild, PreschoolEnterovirus InfectionsFemaleHumansIncidenceInfantInfant, NewbornMaleMeningitis, ViralMiddle AgedRetrospective StudiesSerotypingSpainAtribución-NoComercial-CompartirIgual 4.0 Internacional109820741243497-50610.1017/s09502688990037261469-4409Epidemiology and infectionopen access