Enríquez, José AMittelbrunn, María2025-12-092025-12-092024-07-02https://hdl.handle.net/20.500.12105/26990Tumor cells rewire their metabolism to fulfill the demands of highly proliferative cells. This changes cellular metabolism to adapt to fuel and oxygen availability for energy production and to increase the synthesis capacity of building blocks for cell division and growth. In addition, the metabolic shift modulates the immunogenicity of the tumor cells. Recently, Mahmood and colleagues reported a connection between mitochondrial DNA mutations in cancer cells and their response to immunotherapy in a mouse model of melanoma.This work was conducted in the Mittelbrunn lab supported by a Y2020/ BIO-6350 NutriSION-CM synergy grant from Comunidad de Madrid (Spain) and Spanish Ministerio de Ciencia e Innovacion ´ (PID2022-141169OB-I00) grants and in the Enriquez lab supported by PID2021-1279880B funded by MICINN/AEI/ 10.13039/501100011033 and the European Union “NextGenerationEU”/Plan de Recuperacion ´ Transformacion ´ y Resiliencia-PRTR; TED2021-131611B-I00 funded by MICINN/AEI/10.13039/501100011033 and European Union NextGenerationEU/ PRTR; and Centro de Investigaciones Biome´dicas en Red en Fragilidad y Envejecimiento Saludable (CIBERFES) funded by Instituto de Salud Carlos III and 17CVD04 grant from Foundation Leducq. The Centro Nacional de Investigaciones Cardiovasculares Carlos III is supported by the Instituto de Salud Carlos III, the Ministerio de Ciencia e Innovacio´n, and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033).engCVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 International3865710784(13)2043-2045CANCER RESEARCHopen access