Gomez-Florit, ManuelPacha-Olivenza, Miguel AFernandez-Calderon, Maria CCordoba, AlbaGonzalez-Martin, Maria LMonjo, MartaRamis, Joana Maria2024-07-092024-07-092016-03-01Gomez-Florit M, Pacha-Olivenza MA, Fernandez-Calderon MC, Cordoba A, Gonzalez-Martin ML, Monjo M, et al. Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria. Sci Rep. 2016 Mar 01;6:22444.2045-2322http://hdl.handle.net/20.500.13003/10447http://hdl.handle.net/20.500.12105/20254Many dental implants fail due to the infection and inflammation that walk hand in hand with poor healing and soft tissue integration. Titanium surfaces were nanocoated with quercitrin, a natural flavonoid, with the aim to improve soft tissue integration and increase dental implants success. Streptococcus mutans attachment and biofilm formation was analysed. Then, the anti-inflammatory properties and the potential of quercitrin-nanocoated surfaces to boost soft tissue regeneration were tested using human gingival fibroblasts. An inflammatory situation was mimicked using interleulin-1-beta. We found that quercitrin-nanocoated surfaces decreased initial bacterial adhesion while increasing human gingival fibroblasts attachment. Furthermore, quercitrin-nanocoated Ti increased collagen mRNA levels and decreased matrix metalloproteinase-1/tissue inhibitor of metalloproteinanse-1 mRNA ratio, which is related to a reduced metalloproteinase-mediated collagen degradation, while also decreasing the pro-inflammatory prostaglandin E-2 release under basal and inflammatory conditions. These results suggest that quercitrin-nanocoated surfaces could enhance the soft tissue integration and increase dental implants success.enghttp://creativecommons.org/licenses/by/4.0/Matrix Metalloproteinase 1BiofilmsYoung AdultAdultAnti-Bacterial AgentsCell AdhesionHumansInflammationCells, CulturedBacterial AdhesionAnti-Inflammatory AgentsGingivaMiddle AgedMaleDental ImplantsFemaleDinoprostoneStreptococcus mutansTissue Inhibitor of Metalloproteinase-1QuercetinTitaniumresearch articleAttribution 4.0 International2692555362244410.1038/srep22444Scientific Reportsopen accessDinoprostonaTitanioInhibidor Tisular de Metaloproteinasa-1Implantes DentalesMetaloproteinasa 1 de la MatrizFemeninoEncíaMasculinoAntiinflamatoriosHumanosPersona de Mediana EdadAdulto JovenAdhesión BacterianaCélulas CultivadasInflamaciónAdhesión CelularQuercetinaAdultoAntibacterianosBiopelículasStreptococcus mutans2-s2.0-84959567765371037000003L616507039