Olson, Ashley DWalker, A SarahSuthar, Amitabh BSabin, CarolineBucher, Heiner CJarrin Vera, InmaculadaMoreno, SantiagoPérez-Hoyos, SantiagoPorter, KholoudFord, DeborahCASCADE Collaboration in EuroCoord2019-03-202019-03-202016-09-01J Acquir Immune Defic Syndr. 2016 Sep 1;73(1):100-8.1525-4135http://hdl.handle.net/20.500.12105/7358BACKGROUND: Viremia copy-years (VCY), a time-updated measure of cumulative HIV exposure, predicts AIDS/death; although its utility in deciding when to start combination antiretroviral therapy (cART) remains unclear. We aimed to assess the impact of initiating versus deferring cART on risk of AIDS/death by levels of VCY both independent of and within CD4 cell count strata ≥500 cells per cubic millimeter. METHODS: Using Concerted Action on Seroconversion to AIDS and Death in Europe (CASCADE) data, we created a series of nested "trials" corresponding to consecutive months for individuals ≥16 years at seroconversion after 1995 who were cART-naive and AIDS-free. Pooling across all trials, time to AIDS/death by CD4, and VCY strata was compared in those initiating vs. deferring cART using Cox models adjusted for: country, sex, risk group, seroconversion year, age, time since last HIV-RNA, and current CD4, VCY, HIV-RNA, and mean number of previous CD4/HIV-RNA measurements/year. RESULTS: Of 9353 individuals, 5312 (57%) initiated cART and 486 (5%) acquired AIDS/died. Pooling CD4 strata, risk of AIDS/death associated with initiating vs. deferring cART reduced as VCY increased. In patients with high CD4 cell counts, ≥500 cells per cubic millimeter, there was a trend for a greater reduction for those initiating vs. deferring with increasing VCY (P = 0.09), with the largest benefit in the VCY ≥100,000 copy-years/mL group [hazard ratio (95% CI) = 0.41 (0.19 to 0.87)]. CONCLUSIONS: For individuals with CD4 ≥500 cells per cubic millimeter, limiting the cumulative HIV burden to <100,000 copy-years/mL through cART may reduce the risk of AIDS/death.engVoRhttp://creativecommons.org/licenses/by-nc/4.0/Acquired Immunodeficiency SyndromeAdolescentAdultCD4 Lymphocyte CountFemaleHIV InfectionsHumansMaleMiddle AgedViremiaYoung AdultAtribución-NoComercial- 4.0 Internacional27116045731100-810.1097/QAI.00000000000010291944-7884Journal of acquired immune deficiency syndromes (1999)open access