Hesse, KerrickAung, NayPetersen, Steffen ESiripanthong, BhurintCaptur, GabriellaYeo, Khung KeongFriedrich, Matthias GJaddoe, Vincent W VDörr, MarcusPischon, TobiasBluemke, David AIbáñez, BorjaFuster, ValentinChahal, C Anwar AKhanji, Mohammed Y2026-04-272026-04-272026-02-20JACC Cardiovasc Imaging. 2026 Feb 20:S1936-878X(26)00050-1.https://hdl.handle.net/20.500.12105/27445Epidemiological population studies may include cardiac magnetic resonance (CMR)-derived phenotyping and large-scale genotyping, providing unprecedented level of detail to investigate novel gene-lifestyle-disease interactions. The systematic review presents high-level summaries and critically appraises contemporary challenges and biobank opportunities. The authors identified 17 relevant biobanks by searching "CMR," "genome" and "population study" on MEDLINE, EMBASE, and Web of Science 2025. Collectively, studies recruited ∼1 million participants with stored blood samples for extensive genomic analyses, of whom >180,000 have or will undergo CMR. Use of expansive personal data must safeguard participant confidentiality, encourage technological standardization, and champion inclusivity and sustainability. Application of genotypic and imaging-derived phenotypic information will be readily translatable to clinical practice through investigation of, among others, new therapeutic targets and highly sensitive and specific biomarkers. Imaging biobanks are accessible to researchers by application. This systematic review should inspire greater use and cross-collaboration and facilitate powerful discoveries in more heterogeneous population samples.Dr Hesse has been supported by a British Heart Foundation Clinical Research Training Fellowship number FS/CRTF/23/24428. Dr Aung has received support from Medical Research Council for his Clinician Scientist Fellowship (MR/X020924/1). Dr Petersen has received grants from the European Union’s Horizon 2020 research and innovation program under grant agreement number 825903 (euCanSHare project), the British Heart Foundation for funding the manual analysis to create a cardiac magnetic resonance reference standard for the UK Biobank imaging resource in 5000 CMR scans (www.bhf.org.uk; PG/14/89/31194, “SmartHeart” EPSRC program grant (www.nihr.ac.uk; EP/P001009/1); and has received consulting fees from Cardiovascular Imaging Inc, Calgary, Alberta, Canada. Dr Captur has received grants from the British Heart Foundation (BHF, MyoFit46 Special Programme Grant SP/20/2/34841), the BHF Accelerator Award (AA/18/6/34223), the NIHR Invention for Innovation FAST grant scheme (iFAST NIHR205960), and the NIHR UCL Hospitals Biomedical Research Centre (BRC). Dr Yeo has received grant support for the SingHEART study conducted at the National Heart Centre Singapore by the Lee Foundation and in memory of Mr Henry H.L. Kwee, SingHealth and Duke-NUS Institute of Precision Medicine (PRISM); and has received a center grant awarded to the National Heart Centre Singapore from the National Medical Research Council, Ministry of Health, Singapore (CGAug16M006 and NMRC/CG1/003/2021-NHCS). Dr Friedrich is shareholder of Area19 Medical Inc, Montreal, Quebec, Canada and Circle Cardiovascular Imaging Inc, Calgary, Alberta, Canada. Dr Pischon has received grants from NAKO by the Federal Ministry of Education and Research (BMBF) [project funding reference numbers: 01ER1301A/B/C, 01ER1511D, 01ER1801A/ B/C/D and 01ER2301A/B/C], federal states of Germany and the Helmholtz Association, and the participating universities and the institutes of the Leibniz Association. Dr Bluemke has received consulting fees from GE HealthCare. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.engVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/cardiovascular magnetic resonancegenomicspopulation studyAttribution-NonCommercial-NoDerivatives 4.0 International41758108JACC. Cardiovascular Imagingopen access