García de la Sota, PatriciaLorente, ElenaNotario, LauraMir-Gerrero, CarmenZaragoza, OscarLopez, Daniel2022-05-032022-05-032021-09-07Biomedicines. 2021;9(9):1176.2227-9059http://hdl.handle.net/20.500.12105/14234Human respiratory syncytial virus (HRSV) is the most common cause of severe respiratory infections in infants and young children, often leading to hospitalization. In addition, this virus poses a serious health risk in immunocompromised individuals and the elderly. HRSV is also a major nosocomial hazard in healthcare service units for patients of all ages. Therefore, the development of antiviral treatments against HRSV is a global health priority. In this study, mitoxantrone, a synthetic anthraquinone with previously reported in vitro antiprotozoal and antiviral activities, inhibits HRSV replication in vitro, but not in vivo in a mice model. These results have implications for preclinical studies of some drug candidates.engVoRhttp://creativecommons.org/licenses/by/4.0/HRSVAntiviralsBioluminescenceDrugsAtribución 4.0 Internacional3457236299117610.3390/biomedicines9091176Biomedicinesopen access