Caja, SergioEnriquez, Jose Antonio2017-10-202017-10-202017Redox Biol. 2017; 12:821-8272213-2317http://hdl.handle.net/20.500.12105/5104The involvement of angiogenesis in disease and its potential as a therapeutic target have been firmly established over recent decades. Endothelial cells (ECs) are central elements in vessel homeostasis and regulate the passage of material and cells into and out of the bloodstream. EC proliferation and migration are modified by alterations to mitochondrial biogenesis and dynamics resulting from several signals and environmental cues, such as oxygen, hemodynamics, and nutrients. As intermediary signals, mitochondrial ROS are released as important downstream modulators of the expression of angiogenesis-related genes. In this review, we discuss the physiological actions of these signals and aberrant responses during vascular disorders.engVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/Endothelial cellsMitochondriaBiogenesisDynamicsROSDYNAMIN-RELATED PROTEIN-1VASCULAR SMOOTH-MUSCLELAMINAR SHEAR-STRESSBLOOD-BRAIN-BARRIEROXYGEN SPECIES ROSOXIDATIVE STRESSANGIOTENSIN-IINITRIC-OXIDECARDIOVASCULAR-SYSTEMADHESION MOLECULE-1Attribution-NonCommercial-NoDerivatives 4.0 Internacional2844894312821-82710.1016/j.redox.2017.04.021Redox Biologyopen access