Khoury, NadineMartínez, María ÁngelesPaz-Graniel, IndiraMartínez-González, Miguel ÁngelCorella, DoloresCastañer, OlgaMartínez, J AlfredoAlonso-Gómez, Ángel MWärnberg, JuliaVioque, JesusRomaguera, DoraLópez-Miranda, JoséEstruch, RamonTinahones, Francisco JLapetra, JoséSerra-Majem, LluisBueno-Cavanillas, AuroraTur, Josep ASanjurjo, Sergio CinzaPintó, XavierGaforio, José JuanMatía-Martín, PilarVidal, JosepVazquez, ClotildeDaimiel, LidiaRos, EmilioSayon-Orea, CarmenSorli, Jose V.Pérez-Vega, Karla-AlejandraGarcia-Rios, AntonioBellvert, Nuria GómezGómez-Gracia, EnriqueZulet, MAChaplin, AliceCasas, RosaSalcedo-Bellido, InmaculadaTojal-Sierra, LucasRosa Bernal-Lopez, MariaVazquez-Ruiz, ZenaidaAsensio, Eva MGoday, AlbertPeña-Orihuela, Patricia JSignes-Pastor, Antonio JGarcia-Arellano, AnaFito, MontserratBabio, NancySalas-Salvado, Jordi2024-10-092024-10-092023-06-15Khoury N, Martínez MÁ, Paz-Graniel I, Martínez-González MÁ, Corella D, Castañer O, et al. Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status. Environ Res. 2023 Jun;227:115697.https://hdl.handle.net/20.500.13003/18975https://hdl.handle.net/20.500.12105/23634Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods: In 5899 participants aged 55-75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results.enghttp://creativecommons.org/licenses/by/4.0/DioxinsHumansEatingMiddle AgedCross-Sectional StudiesFuransMaleProspective StudiesFemaleAdiposityDibenzofurans, PolychlorinatedDibenzofuransPolychlorinated DibenzodioxinsOverweightPolychlorinated BiphenylsObesity, Abdominalresearch articleAtribución 4.0 Internacional3697277522711569710.1016/j.envres.2023.1156971096-0953Environmental researchopen accessFemeninoDibenzofuranos PolicloradosDibenzodioxinas PolicloradasDibenzofuranosMasculinoDioxinasFuranosObesidad AbdominalEstudios TransversalesPersona de Mediana EdadHumanosEstudios ProspectivosIngestión de AlimentosBifenilos PolicloradosSobrepesoAdiposidad2-s2.0-85151281178970314500001L2023596856