Peinado, HéctorOlmeda, DavidCano, Amparo2024-02-052024-02-052007-06Nat Rev Cancer. 2007;7(6):415-281474-175Xhttp://hdl.handle.net/20.500.12105/17456The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial-mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications.engSMURhttp://creativecommons.org/licenses/by-nc-nd/4.0/Neoplasm InvasivenessCadherinsCell AdhesionCell MovementDisease ProgressionEpitheliumHelix-Turn-Helix MotifsHomeodomain ProteinsHumansModels, BiologicalNeoplasmsPhenotypeProtein Processing, Post-TranslationalRepressor ProteinsSignal TransductionSnail Family Transcription FactorsTranscription FactorsZinc Finger E-box-Binding Homeobox 1Attribution-NonCommercial-NoDerivatives 4.0 Internacional175080287641510.1038/nrc2131Nature reviews. Canceropen access