Orive, MirenAnton-Ladislao, AneLázaro, SantiagoGonzález, NereaBaré, MarisaFernandez de Larrea-Baz, NereaRedondo, MaximinoBilbao, AmaiaSarasqueta, CristinaAguirre, UrkoQuintana, Jose MariaREDISSEC-CARESS/CCR group2023-04-122023-04-122022-10Support Care Cancer. 2022 Oct;30(10):7943-7954.0941-4355http://hdl.handle.net/20.500.12105/15788Purpose: Health-related quality of life (HRQoL) measurement represents an important outcome in cancer patients. We describe the evolution of HRQoL over a 5-year period in colorectal cancer patients, identifying predictors of change and how they relate to mortality. Methods: Prospective observational cohort study including colorectal cancer (CRC) patients having undergone surgery in nineteen public hospitals who were monitored from their diagnosis, intervention and at 1-, 2-, 3-, and 5-year periods thereafter by gathering HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Multivariable generalized linear mixed models were used. Results: Predictors of Euroqol-5D-5L (EQ-5D-5L) changes were having worse baseline HRQoL; being female; higher Charlson index score (more comorbidities); complications during admission and 1 month after surgery; having a stoma after surgery; and needing or being in receipt of social support at baseline. For EORTC-QLQ-C30, predictors of changes were worse baseline EORTC-QLQ-C30 score; being female; higher Charlson score; complications during admission and 1 month after admission; receiving adjuvant chemotherapy; and having a family history of CRC. Predictors of changes in HADS anxiety were being female and having received adjuvant chemotherapy. Greater depression was associated with greater baseline depression; being female; higher Charlson score; having complications 1 month after intervention; and having a stoma. A deterioration in all HRQoL questionnaires in the previous year was related to death in the following year. Conclusions: These findings should enable preventive follow-up programs to be established for such patients in order to reduce their psychological distress and improve their HRQoL to as great an extent as possible.engVoRhttp://creativecommons.org/licenses/by/4.0/Colorectal cancerPatient-reported outcome measuresHealth-related quality of lifeCohort studiesLongitudinal studiesColorectal NeoplasmsQuality of LifeAnxietyDepressionFemaleFollow-Up StudiesHumansMaleProspective StudiesAtribución 4.0 Internacional3573714330107943-795410.1007/s00520-022-07177-11433-7339Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Canceropen access