Martínez-Urbistondo, DiegoSan Cristóbal, RodrigoSanVillares, PaulaMartínez-González, Miguel ÁngelBabio, NancyCorella, DoloresDel Val, José LuisOrdovás, José MAlonso-Gómez, Ángel MWärnberg, JuliaVioque, JesúsRomaguera, DoraLópez-Miranda, JoséEstruch, RamonTinahones, Francisco JLapetra, JoséSerra-Majem, J LuísBueno-Cavanillas, AuroraTur, Josep AMarcos, AlbaPintó, XavierDelgado-Rodríguez, MiguelMatía-Martín, PilarVidal, JosepVázquez, ClotildeRos, EmilioBullón Vela, María VanessaPalau, AntoniMasagué, MartaAbete, ItziarMoreno-Rodríguez, AnaiCandela-García, InmaKonieczna, JadwigaGarcía-Ríos, AntonioJuárez, Oscar LeceaMartín, PacoGoday, AlbertZulet, M ÁngelesVaquero-Luna, JessicaOrea, María Del Carmen SayónMegías, IsabelBaltasar, EnricMartínez, J AlfredoDaimiel, Lidia2024-02-272024-02-272022-06-29Martínez-Urbistondo D, San Cristóbal R, Villares P, Martínez-González MÁ, Babio N, Corella D, et al. Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort. Front Endocrinol (Lausanne). 2022 Jun 29;13.1664-2392http://hdl.handle.net/10668/20564http://hdl.handle.net/20.500.13003/18128http://hdl.handle.net/20.500.12105/18690Objective: To evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic syndrome (MetS). Methods: Baseline and 1 year follow up data from the PREDIMED-plus cohort (men and women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as affected by lifestyle during 1 year of follow up. Results: Data from 5205 patients with mean age of 65 years and a 48% of female participants. Adjusted linear multivariate mixed regression models showed that patients with lower probability of NAFLD (HSI < 36 points) were more responsive to er-MeDiet (β 0.64 vs β 0.05 per er-MeDiet adherence point, p< 0.01) and PA (β 0.05 vs β 0.01 per MET-h/week, p = 0.001) than those with high probability for NAFLD in terms Physical SF-36 summary in the 1 year follow up. 10 points of er-MeDiet adherence and 50 MET-h/week were thresholds for a beneficial effect of lifestyle on HRQoL physical domain in patients with lower probability of NAFLD. Conclusion: The evaluation of NAFLD by the HSI index in patients with MetS might identify subjects with different prospective sensitivity to lifestyle changes in terms of physical HRQoL (http://www.isrctn.com/ISRCTN89898870).engVoRhttp://creativecommons.org/licenses/by/4.0/HRQoLNAFLDMediterranean dietMetabolic syndromePhysical activityAgedFemaleHumansLife StyleMaleMetabolic SyndromeMiddle AgedNon-alcoholic Fatty Liver DiseaseProspective StudiesQuality of LifeAttribution 4.0 International358462911386879510.3389/fendo.2022.868795Frontiers in endocrinologyopen accessHumanosPersona de Mediana EdadCalidad de VidaEstudios ProspectivosSíndrome MetabólicoEstilo de VidaAncianoEnfermedad del Hígado Graso no AlcohólicoFemeninoMasculino2-s2.0-85134176497835976900001L2018233028