Effectiveness of influenza vaccines in children aged 6 to 59 months: a test-negative case-control study at primary care and hospital level, Spain 2023/24

Pérez-Gimeno, GloriaMazagatos, ClaraLorusso, NicolaBasile, LucaMartínez-Pino, IsabelCorpas-Burgos, FranciscaBatalla Rebolla, NoaRumayor-Zarzuelo, Mercedes BelénAndreu Ivorra, BlancaGiménez Duran, JaumeCastrillejo, DanielGuiu Cañete, InésHuerta Huerta, MartaGarcía Becerril, MartaRamos Marín, VioletaCasas Flecha, InmaculadaPozo Sanchez, FranciscoMonge Corella, SusanaSiVIRA group2024-10-302024-10-302024-10Euro Surveill. 2024 Oct;29(40):2400618.1025-496Xhttps://hdl.handle.net/20.500.12105/25380During 2023/24, all children aged 6 to 59 months were targeted for seasonal influenza vaccination in Spain nationally. Using a test-negative case-control design with sentinel surveillance data, we estimated adjusted influenza vaccine effectiveness (IVE) against any influenza type to be 70% (95% confidence interval (CI): 51 to 81%) for primary care patients with acute respiratory illness (ARI) and 77% (95% CI: 21 to 93%) for hospitalised patients with severe ARI. In primary care, where most subtyped viruses (61%; 145/237) were A(H1N1), adjusted IVE was 77% (95% CI: 56 to 88%) against A(H1N1)pdm09.engVoRhttp://creativecommons.org/licenses/by/4.0/ChildrenInfluenzaTest-negative designVaccine effectivenessCase-Control StudiesChild, PreschoolFemaleHospitalizationHospitalsHumansInfantInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza B virusInfluenza VaccinesInfluenza, HumanMalePrimary Health CareSeasonsSentinel SurveillanceSpainVaccinationVaccine EfficacyEffectiveness of influenza vaccines in children aged 6 to 59 months: a test-negative case-control study at primary care and hospital level, Spain 2023/24Attribution 4.0 International393646012940240061810.2807/1560-7917.ES.2024.29.40.24006181560-7917Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletinopen access