Díez, CristinaDel Romero-Raposo, JorgeMicán, RafaelLópez, Juan CBlanco, José RamónCalzado, SoniaSamperiz, GloriaPortilla, JoaquínGarcía-Fraile, Lucio JesúsGutiérrez, FélixGómez-Sirvent, Juan LSuárez-García, InésAmador, ConchaNovella, MaríaArribas, José RMoreno, SantiagoGonzález-García, JuanJarrin Vera, InmaculadaBerenguer, JuanCoRIS Cohort2022-04-252022-04-252021-10HIV Medicine. 2021 Oct;22(9):867-876.http://hdl.handle.net/20.500.12105/14164Objectives: We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods: This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results: Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/μL. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions: Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization.engVoRhttps://creativecommons.org/licenses/by-nc/4.0/COVID-19CoronavirusHIVSARS-CoV-2Attribution-NonCommercial 4.0 International34324783229867-87610.1111/hiv.131451468-1293HIV Medicineopen access