Valle-Hita, CristinaDíaz-López, AndrésBecerra-Tomás, NereaMartínez-González, Miguel AGarcía, Verónica RuizCorella, DoloresGoday, AlbertMartínez, J AlfredoAlonso-Gómez, Ángel MWärnberg, JuliaVioque, JesúsRomaguera, DoraLópez-Miranda, JoséEstruch, RamonTinahones, Francisco JLapetra, JoséSerra-Majem, LuísCano-Ibáñez, NaomiTur, Josep ARubín-García, MaríaPintó, XavierDelgado-Rodríguez, MiguelMatía-Martín, PilarVidal, JosepFontao, Sebastian MasDaimiel, LidiaRos, EmilioToledo, EstefaniaSorlí, José VRoca, CAbete, IztiarMoreno-Rodriguez, AnaiCrespo-Oliva, EdelysCandela-García, InmaculadaMorey, MargaGarcia-Rios, AntonioCasas, RosaFernández-García, José CarlosSantos-Lozano, José ManuelDiez-Espino, JavierOrtega-Azorín, CarolinaComas, MZulet, M AngelesSorto-Sanchez, CarolinaRuiz-Canela, MiguelFitó, MontseSalas-Salvadó, JordiBabio, Nancy2024-02-272024-02-272022-04-02Valle-Hita C, Diaz-Lopez A, Becerra-Tomas N, Martinez-Gonzalez MA, Garcia VR, Corella D, et al. Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk. Eur J Nutr. 2022 Sep;61(6):3095-108. Epub 2022 Apr 2.http://hdl.handle.net/10668/19908https://hdl.handle.net/20.500.13003/19774http://hdl.handle.net/20.500.12105/18804Purpose: To assess the association between three different a priori dietary patterns adherence (17-item energy reduced-Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as well as the Protein Diet Score and kidney function decline after one year of follow-up in elderly individuals with overweight/obesity and metabolic syndrome (MetS). Methods: We prospectively analyzed 5675 participants (55-75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m2) or ≥ 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate. Results: Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (β: 1.87 ml/min/1.73m2; 95% CI: 1.00-2.73) and had lower odds of ≥ 10% eGFR decline (OR: 0.62; 95% CI: 0.47-0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (β: - 0.87 ml/min/1.73m2; 95% CI: - 1.73 to - 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00-1.75). Conclusions: Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health.engVoRhttp://creativecommons.org/licenses/by/4.0/DASH dietDietary patternsGlomerular filtration rateKidney functionMediterranean dietProtein diet scoreAgedCardiovascular DiseasesDiet, MediterraneanHeart Disease Risk FactorsHumansHypertensionKidneyMetabolic SyndromeObesityOverweightRisk FactorsAttribution 4.0 International353667086163095-310810.1007/s00394-022-02838-71436-6215European journal of nutritionopen accessRiñónDieta MediterráneaHipertensiónFactores de RiesgoHumanosObesidadFactores de Riesgo de Enfermedad CardiacaSíndrome MetabólicoAncianoEnfermedades CardiovascularesSobrepeso2-s2.0-85127591831777379000002L2015498300