Ramos-Sesma, VioletaNavarro, MiriamLlenas-García, JaraGil-Anguita, ConcepciónTorrús-Tendero, DiegoWikman-Jorgensen, PhilipAmador-Prous, ConcepciónVentero-Martín, María-PazGarijo-Sainz, Ana-MaríaGarcía-López, MaríaPujades-Tarraga, Ana-IsabelBernal-Alcaraz, CristinaSantonja, AntonioGuevara-Hernández, PedroFlores-Chavez, MariaSaugar, Jose MariaRamos-Rincón, José-ManuelCorazones Sin Chagas Platform2022-09-012022-09-012020-06-24Pathogens. 2020 Jun 24;9(6):511.2076-0817http://hdl.handle.net/20.500.12105/14924Strongyloides stercoralis infection is frequently underdiagnosed since many infections remain asymptomatic. Aim: To estimate the prevalence and characteristics of asymptomatic S. stercoralis infection in Latin American migrants attending a community-based screening program for Chagas disease in Spain. Methodology: Three community-based Chagas disease screening campaigns were performed in Alicante (Spain) in 2016, 2017, and 2018. Serological testing for S. stercoralis infection was performed using a non-automatized IVD-ELISA detecting IgG (DRG Instruments GmbH, Marburg, Germany). Results: Of the 616 migrants from Central and South America who were screened, 601 were included in the study: 100 children and adolescents (<18 years of age) and 501 adults. Among the younger group, 6 participants tested positive (prevalence 6%, 95% confidence interval [CI] 2.5% to 13.1%), while 60 adults did so (prevalence 12%, 95% CI 9.3% to 15.3%). S. stercoralis infection was more common in men than in women (odds ratio adjusted [ORa] 2.28, 95% CI 1.289 to 4.03) and in those from Bolivia (ORa 2.03, 95% CI 1.15 to 3.59). Prevalence increased with age (ORa 1.02, 95% CI 0.99 to 1.05). In contrast, a university education had a protective effect (ORa 0.29, 95% CI 0.31 to 0.88). Forty-one (41/66; 62.1%) of the total cases of S. stercoralis infection were treated at the health care center. Positive stool samples were observed in 19.5% of the followed-up positive cases. Conclusion: Incorporating serological screening for S. stercoralis into community-based screening for Chagas disease is a useful intervention to detect asymptomatic S. stercoralis infection in Central and South American migrants and an opportunity to tackle neglected tropical diseases in a transversal way. The remaining challenge is to achieve patients' adherence to the medical follow-up.engVoRhttp://creativecommons.org/licenses/by/4.0/Central and South AmericaChagas diseaseCommunity-based interventionStrongyloides stercoralisStrongyloidiasisMigrantsAtribución 4.0 Internacional325998719651110.3390/pathogens9060511Pathogens (Basel, Switzerland)open access