Gómez-Grande, AdolfoSeiffert, Alexander PVillarejo-Galende, AlbertoGonzález-Sánchez, MartaLlamas-Velasco, SaraBueno, HectorGómez, Enrique JTabuenca, María JoséSánchez-González, Patricia2024-05-092024-05-092023Rev Esp Med Nucl Imagen Mol (Engl Ed). 2023 Jul-Aug;42(4):211-217.http://hdl.handle.net/20.500.12105/19311OBJECTIVE To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with 18F-labeled amyloid-binding radiotracers and brain [18F]FDG PET in patients with primary progressive aphasia (PPA). MATERIAL AND METHODS The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9 nonfluent variant PPA, 4 logopenic variant PPA, 1 semantic variant PPA, 3 unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [18F]FDG PET images and Pearson's correlation coefficients are calculated. RESULTS SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of r=0.94±0.06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images. CONCLUSIONS The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.engVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/Fluorodeoxyglucose F18Aphasia, Primary ProgressiveHumansBrainPositron-Emission TomographyAmyloidAttribution-NonCommercial-NoDerivatives 4.0 Internacional3675882842421110.1016/j.remnie.2023.02.0012253-8089Revista espanola de medicina nuclear e imagen molecularopen access