Diz-de Almeida, SilviaCruz, RaquelLuchessi, Andre DLorenzo-Salazar, José MLópez de Heredia, MiguelQuintela, InésGonzález-Montelongo, RafaelaNogueira Silbiger, VivianPorras, Marta SevillaTenorio Castaño, Jair AntonioNevado, JuliánAguado, José MaríaAguilar, CarlosAguilera-Albesa, SergioAlmadana, VirginiaAlmoguera, BertaAlvarez, NuriaAndreu-Bernabeu, ÁlvaroArana-Arri, EunateArango, CelsoArranz, María JArtiga, Maria-JesusBaptista-Rosas, Raúl CBarreda-Sánchez, MaríaBelhassen-García, MoncefBezerra, Joao FBezerra, Marcos A CBoix-Palop, LucíaBrion, MaríaBrugada, RamónBustos, MatildeCalderón, Enrique JCarbonell, CristinaCastano, LuisCastelao, Jose EConde-Vicente, RosaCordero-Lorenzana, M LourdesCortes-Sanchez, Jose LCorton, MartaDarnaude, M TeresaDe Martino-Rodríguez, AlbaDel Campo-Pérez, VictorDiaz de Bustamante, AranzazuDomínguez-Garrido, ElenaEirós, RocíoFariñas, María CarmenFernandez-Nestosa, María JFernández-Robelo, UxíaFernandez-Rodriguez, AmandaFernández-Villa, TaniaGago-Dominguez, ManuelaGil-Fournier, BelénGómez-Arrue, JavierGonzález Álvarez, BeatrizGonzález Bernaldo de Quirós, FernanGonzález-Neira, AnnaGonzález-Peñas, JavierGutiérrez-Bautista, Juan FHerrero, María JoséHerrero-Gonzalez, AntonioJimenez-Sousa, Maria AngelesLattig, María ClaudiaLiger Borja, AnabelLopez-Rodriguez, RosarioMancebo, EstherMartín-López, CaridadMartín, VicenteMartinez-Nieto, OscarMartinez-Lopez, IciarMartinez-Resendez, Michel FMartinez-Perez, AngelMazzeu, Juliana FMerayo Macías, EleuterioMinguez, PabloMoreno Cuerda, VictorOliveira, Silviene FOrtega-Paino, EvaPompa-Mera, Ericka NParellada, MaraPaz-Artal, EstelaSantos, Ney PCPérez-Matute, PatriciaPerez, PatriciaPérez-Tomás, M ElenaPerucho, TeresaPinsach-Abuin, Mel·linaPita, GuillermoPorras-Hurtado, Gloria LPujol, AuroraRamiro León, SorayaResino, SalvadorFernandes, Marianne RRodríguez-Ruiz, EmilioRodríguez-Artalejo, FernandoRodriguez-Garcia, José ARuiz-Cabello, FranciscoRuiz-Hornillos, JavierRyan, PabloSoria, José ManuelSouto, Juan CarlosTamayo, EduardoTamayo-Velasco, ÁlvaroTaracido-Fernandez, Juan CarlosTeper, AlejandroTorres-Tobar, LilianUrioste, MiguelValencia-Ramos, JuanYáñez, ZuleimaZarate, Ruthde Rojas, ItziarRuiz, AgustínSánchez, PascualReal, Luis MiguelSCOURGE Cohort GroupGuillén-Navarro, EncarnaAyuso, CarmenParra, EstebanRiancho, José ARojas-Martinez, AugustoFlores, Carlos2025-02-212025-02-212024-10-03Diz-de Almeida S, Cruz R, Luchessi AD, Lorenzo-Salazar JM, de Heredia ML, Quintela I, González-Montelongo R, Nogueira Silbiger V, Porras MS, Tenorio Castaño JA, Nevado J, Aguado JM, Aguilar C, Aguilera-Albesa S, Almadana V, Almoguera B, Alvarez N, Andreu-Bernabeu Á, Arana-Arri E, Arango C, Arranz MJ, Artiga MJ, Baptista-Rosas RC, Barreda-Sánchez M, Belhassen-Garcia M, Bezerra JF, Bezerra MAC, Boix-Palop L, Brion M, Brugada R, Bustos M, Calderón EJ, Carbonell C, Castano L, Castelao JE, Conde-Vicente R, Cordero-Lorenzana ML, Cortes-Sanchez JL, Corton M, Darnaude MT, De Martino-Rodríguez A, Del Campo-Pérez V, de Bustamante AD, Domínguez-Garrido E, Eirós R, Fariñas MC, Fernandez-Nestosa MJ, Fernández-Robelo U, Fernández-Rodríguez A, Fernández-Villa T, Gago-Dominguez M, Gil-Fournier B, Gómez-Arrue J, Álvarez BG, Bernaldo de Quirós FG, González-Neira A, González-Peñas J, Gutiérrez-Bautista JF, Herrero MJ, Herrero-Gonzalez A, Jimenez-Sousa MA, Lattig MC, Borja AL, Lopez-Rodriguez R, Mancebo E, Martín-López C, Martín V, Martinez-Nieto O, Martinez-Lopez I, Martinez-Resendez MF, Martinez-Perez A, Mazzeu JF, Macías EM, Minguez P, Cuerda VM, Oliveira SF, Ortega-Paino E, Parellada M, Paz-Artal E, Santos NPC, Pérez-Matute P, Perez P, Pérez-Tomás ME, Perucho T, Pinsach-Abuin M, Pita G, Pompa-Mera EN, Porras-Hurtado GL, Pujol A, León SR, Resino S, Fernandes MR, Rodríguez-Ruiz E, Rodriguez-Artalejo F, Rodriguez-Garcia JA, Ruiz-Cabello F, Ruiz-Hornillos J, Ryan P, Soria JM, Souto JC, Tamayo E, Tamayo-Velasco A, Taracido-Fernandez JC, Teper A, Torres-Tobar L, Urioste M, Valencia-Ramos J, Yáñez Z, Zarate R, de Rojas I, Ruiz A, Sánchez P, Real LM; SCOURGE Cohort Group; Guillen-Navarro E, Ayuso C, Parra E, Riancho JA, Rojas-Martinez A, Flores C, Lapunzina P, Carracedo Á. Novel risk loci for COVID-19 hospitalization among admixed American populations. Elife. 2024 Oct 3;13:RP93666.https://hdl.handle.net/20.500.12105/26351Data availability: Summary statistics from the SCOURGE Latin American GWAS and the analysis scripts are avail able from the public repository https://github.com/CIBERER/Scourge-COVID19 (copy archived at CIBERER, 2024)The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations ( and ). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in . Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.spaVoRhttp://creativecommons.org/licenses/by/4.0/COVID-19GWASSNPGeneticsGenomicsNoneAgedCOVID-19FemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHospitalizationHumansLatin AmericaMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsSARS-CoV-2Attribution 4.0 International3936137013RP9366610.7554/eLife.936662050-084Xe-Lifeopen access