Hernando Sebastian, VictoriaAlejos, BelénMonge Corella, SusanaBerenguer, JuanAnta, LourdesVinuesa, DavidPalacios, RosarioMuga, RobertoMoreno, SantiagoJarrin Vera, InmaculadaCoRIS Cohort2019-02-012019-02-012013-08-20BMC Infect Dis. 2013 Aug 20;13:382.1471-2334http://hdl.handle.net/20.500.12105/7061BACKGROUND: Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population. METHODS: We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 person-years (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender. RESULTS: Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997-2003). CONCLUSION: Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection.engVoRhttp://creativecommons.org/licenses/by/4.0/Acquired Immunodeficiency SyndromeAdultCohort StudiesFemaleHumansMaleMiddle AgedRisk FactorsSpainYoung AdultAtribución 4.0 Internacional2396192413138210.1186/1471-2334-13-3821471-2334BMC infectious diseasesopen access