Mascaro, Catalina MBouzas, CristinaTur, Josep A2024-10-042024-10-042022-01Mascaro CM, Bouzas C, Tur JA. Association between Non-Alcoholic Fatty Liver Disease and Mediterranean Lifestyle: A Systematic Review. Nutrients. 2022 Jan;14(1):49.https://hdl.handle.net/20.500.13003/19454https://hdl.handle.net/20.500.12105/23385Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is an excessive accumulation of fat in the liver without alcohol abuse. It is linked to metabolic syndrome (MetS) and no pharmacological treatment exists. This systematic review aims to assess evidence about the effect of Mediterranean lifestyle on the prevention and reversion of NAFLD. Methods: A systematic literature search was performed in MEDLINE via Pubmed. MeSH terms used were: non-alcoholic fatty liver disease [MeSH Major Topic] AND metabolic syndrome [MeSH Term] AND (Diet, Mediterranean [MeSH Term]) OR (Exercise [MeSH Term]). (PROSPERO ID: 2021 CRD42021289495). Results: Thirteen research articles were selected and divided into two categories (four focused on Mediterranean diet and NAFLD and nine focused on Mediterranean diet, physical activity, and NAFLD). Information of clinical endpoints was based on NAFLD, as well as MetS, body mass index, fasting glycemia, obesity, cholesterol, triglycerides, transaminases, albuminuria, and hepatic steatosis, among others. All studies found beneficial associations between the clinical parameters of NAFLD/MetS and following a Mediterranean diet and regular physical activity. Conclusions: An effective treatment that prevents, and even reverses, NAFLD is to adapt lifestyle to the Mediterranean one, based on a Mediterranean diet and regular physical activity.enghttp://creativecommons.org/licenses/by/4.0/Non-alcoholic fatty liver diseaseMediterranean dietPhysical activityMediterranean lifestyleMetabolic syndromeMetabolic SyndromeTriglyceridesAgedBlood GlucoseYoung AdultAdultHumansLife StyleAdolescentMiddle AgedNon-alcoholic Fatty Liver DiseaseObesityMaleFemaleBody Mass IndexDiet, MediterraneanExerciseresearch articleAttribution 4.0 International350109231414910.3390/nu140100492072-6643Nutrientsopen accessÍndice de Masa CorporalDieta MediterráneaEjercicio FísicoSíndrome MetabólicoFemeninoEnfermedad del Hígado Graso no AlcohólicoAdolescenteMasculinoHumanosPersona de Mediana EdadObesidadGlucemiaAdulto JovenEstilo de VidaAncianoTriglicéridosAdulto2-s2.0-85121510888741744100001L2015029374