Guerra, CNavarro, PValverde, A MArribas, MBrüning, JKozak, L PKahn, C RBenito, M2024-09-162024-09-162001-10J Clin Invest . 2001;108(8):1205-13.0021-9738https://hdl.handle.net/20.500.12105/23090Although insulin regulates metabolism in both brown and white adipocytes, the role of these tissues in energy storage and utilization is quite different. Recombination technology using the Cre-loxP approach allows inactivation of the insulin receptor in a tissue-specific manner. Mice lacking insulin receptors in brown adipocytes show an age-dependent loss of interscapular brown fat but increased expression of uncoupling protein-1 and -2. In parallel, these mice develop an insulin-secretion defect resulting in a progressive glucose intolerance, without insulin resistance. This model provides direct evidence for not only a role for the insulin receptors in brown fat adipogenesis, the data also suggest a novel role of brown adipose tissue in the regulation of insulin secretion and glucose homeostasis.engVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/Adipose Tissue, BrownAnimalsDiabetes Mellitus, Type 2FemaleInsulinInsulin ResistanceInsulin SecretionMaleMiceMice, KnockoutMice, TransgenicPhenotypeRNAReceptor, InsulinSignal TransductionTissue DistributionAttribution-NonCommercial-NoDerivatives 4.0 Internacional116026281088120510.1172/JCI13103The Journal of clinical investigationopen access