Rodero, LauraMellado, EmiliaRodríguez, A CarolinaSalve, AngelaGuelfand, LilianaCahn, PedroCuenca-Estrella, ManuelDavel, GracielaRodriguez-Tudela, Juan Luis2019-08-132019-08-132003-11Antimicrob Agents Chemother. 2003 Nov;47(11):3653-6.0066-4804http://hdl.handle.net/20.500.12105/8247Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.engAMhttp://creativecommons.org/licenses/by-nc-sa/4.0/Acquired Immunodeficiency SyndromeAdultAmino Acid SequenceAmino Acid SubstitutionAntifungal AgentsCloning, MolecularCryptococcus neoformansCytochrome P-450 Enzyme SystemDrug Resistance, FungalFluconazoleGenotypeHumansMaleMeningitis, CryptococcalMicrobial Sensitivity TestsMolecular Sequence DataOxidoreductasesPlasmidsPoint MutationRecurrenceSterol 14-DemethylaseAtribución-NoComercial-CompartirIgual 4.0 Internacional1457614047113653-610.1128/aac.47.11.3653-3656.2003Antimicrobial agents and chemotherapyopen access