Barceló Bennasar, AntoniaBauça, Josep MiquelYáñez, Aina MFueyo, LauraGómez Cobo, Cristinade la Pena-Bravo, MonicaPierola Lopetegui, JavierRodriguez, AlbertoSanchez-de-la-Torre, ManuelAbad, JorgeMediano San Andres, OlgaAmilibia, JoseJose Masdeu, MariaTeran, JoaquinMaria Montserrat, JosepMayos, MerceSanchez-de-la-Torre, AliciaBarbe, FerranSpanish Sleep Grp2024-07-092024-07-092016-03-01Barcelo Bennasar A, Bauça JM, Yañez AM, Fueyo L, Gomez Cobo C, De la Peña Bravo M, et al. Impact of Obstructive Sleep Apnea on the Levels of Placental Growth Factor (PlGF) and Their Value for Predicting Short-Term Adverse Outcomes in Patients with Acute Coronary Syndrome. PLoS One. 2016 Mar 01;11(3):e0147686.1932-6203http://hdl.handle.net/20.500.13003/10460http://hdl.handle.net/20.500.12105/20253Background Placental growth factor (PlGF) induces angiogenesis and promotes tissue repair, and plasma PlGF levels change markedly during acute myocardial infarction (AMI). Currently, the impact of obstructive sleep apnea (OSA) in patients with AMI is a subject of debate. Our objective was to evaluate the relationships between PlGF levels and both the severity of acute coronary syndrome (ACS) and short-term outcomes after ACS in patients with and without OSA. Methods A total of 538 consecutive patients (312 OSA patients and 226 controls) admitted for ACS were included in this study. All patients underwent polygraphy in the first 72 hours after hospital admission. The severity of disease and short-term prognoses were evaluated during the hospitalization period. Plasma PlGF levels were measured using an electrochemiluminescence immunoassay. Results Patients with OSA were significantly older and more frequently hypertensive and had higher BMIs than those without OSA. After adjusting for age, smoking status, BMI and hypertension, PlGF levels were significantly elevated in patients with OSA compared with patients without OSA (19.9 pg/mL, interquartile range: 16.6-24.5 pg/mL; 18.5 pg/mL, interquartile range: 14.7-22.7 pg/mL; p<0.001), and a higher apnea-hypopnea index (AHI) was associated with higher PlGF concentrations (p<0.003). Patients with higher levels of PlGF had also an increased odds ratio for the presence of 3 or more diseased vessels and for a Killip score>1, even after adjustment. Conclusions The results of this study show that in patients with ACS, elevated plasma levels of PlGF are associated with the presence of OSA and with adverse outcomes during short-term follow-up.enghttp://creativecommons.org/licenses/by/4.0/Continuous Positive Airway PressureAgedRandomized Controlled Trials as TopicCase-Control StudiesSleep Apnea, ObstructiveHumansMiddle AgedPrognosisPlacenta Growth FactorPregnancy ProteinsMaleBiomarkersFemaleTreatment OutcomeAcute Coronary Syndromeresearch articleAttribution 4.0 International26930634113e014768610.1371/journal.pone.0147686PloS Oneopen accessFactor de Crecimiento PlacentarioResultado del TratamientoBiomarcadoresFemeninoPresión de las Vías Aéreas Positiva ContínuaMasculinoApnea Obstructiva del SueñoHumanosPersona de Mediana EdadPronósticoAncianoProteínas GestacionalesEnsayos Clínicos Controlados Aleatorios como AsuntoSíndrome Coronario AgudoEstudios de Casos y Controles2-s2.0-84962528758371434500005L608996962