del Fresno, CarlosSancho, David2020-04-202020-04-202020-01Immunity. 2020; 52(1):6-81074-7613http://hdl.handle.net/20.500.12105/9619Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology.engAMhttp://creativecommons.org/licenses/by-nc-nd/4.0/Cell DeathHumansInflammationNecrosisReceptors, Cell SurfaceHistonesLectins, C-TypeAttribution-NonCommercial-NoDerivatives 4.0 Internacional319515505216-810.1016/j.immuni.2019.12.0151097-4180Immunityopen access