Porcuna, JesusMínguez-Martínez, JorgeRicote, Mercedes2022-03-032022-03-032021-09-30Int J Mol Sci. 2021 Oct; 22(19): 10573http://hdl.handle.net/20.500.12105/13712Peroxisome proliferator-activated receptors (PPARs) are ligand-modulated nuclear receptors that play pivotal roles in nutrient sensing, metabolism, and lipid-related processes. Correct control of their target genes requires tight regulation of the expression of different PPAR isoforms in each tissue, and the dysregulation of PPAR-dependent transcriptional programs is linked to disorders, such as metabolic and immune diseases or cancer. Several PPAR regulators and PPAR-regulated factors are epigenetic effectors, including non-coding RNAs, epigenetic enzymes, histone modifiers, and DNA methyltransferases. In this review, we examine advances in PPARα and PPARγ-related epigenetic regulation in metabolic disorders, including obesity and diabetes, immune disorders, such as sclerosis and lupus, and a variety of cancers, providing new insights into the possible therapeutic exploitation of PPAR epigenetic modulation.engVoRhttp://creativecommons.org/licenses/by-nc/4.0/Epigenesis, GeneticAnimalsDNA MethylationGene Expression RegulationHumansImmune System DiseasesMetabolic DiseasesNeoplasmsPPAR alphaPPAR gammaAtribución-NoComercial 4.0 Internacional3463891422191057310.3390/ijms2219105731422-0067International journal of molecular sciencesopen access