Amengual-Tugores, Andreu MiquelRáez-Meseguer, CarmenForteza-Genestra, Maria AntóniaMonjo, MartaRamis, Joana Maria2024-10-092024-10-092023-02-18Amengual-Tugores AM, Ráez-Meseguer C, Forteza-Genestra MA, Monjo M, Ramis JM. Extracellular Vesicle-Based Hydrogels for Wound Healing Applications. Int J Mol Sci. 2023 Feb 18;24(4):4104.https://hdl.handle.net/20.500.13003/18921https://hdl.handle.net/20.500.12105/23666Hydrogels and extracellular vesicle-based therapies have been proposed as emerging therapeutic assets in wound closure. The combination of these elements has given good results in managing chronic and acute wounds. The intrinsic characteristics of the hydrogels in which the extracellular vesicles (EVs) are loaded allow for overcoming barriers, such as the sustained and controlled release of EVs and the maintenance of the pH for their conservation. In addition, EVs can be obtained from different sources and through several isolation methods. However, some barriers must be overcome to transfer this type of therapy to the clinic, for example, the production of hydrogels containing functional EVs and identifying long-term storage conditions for EVs. The aim of this review is to describe the reported EV-based hydrogel combinations, along with the obtained results, and analyze future perspectives.enghttp://creativecommons.org/licenses/by/4.0/HydrogelsWound HealingExtracellular Vesiclesresearch articleAtribución 4.0 Internacional3683551624410.3390/ijms240441041422-0067International journal of molecular sciencesopen accessVesículas ExtracelularesCicatrización de HeridasHidrogeles2-s2.0-85149053727944992800001L2021826258