Alshehri, Mohammed MSharifi-Rad, JavadHerrera-Bravo, JesusJara, Evelyn LSalazar, Luis AKregiel, DorotaUprety, YadavAkram, MuhammadIqbal, MehwishMartorell, MiquelTorrens-Mas, MargalidaPons, Daniel GabrielDastan, Sevgi DurnaCruz-Martins, NataliaOzdemir, Fethi AhmetKumar, ManojCho, William C2024-09-182024-09-182021-09-10Alshehri MM, Sharifi-Rad J, Herrera-Bravo J, Jara EL, Salazar LA, Kregiel D, et al. Therapeutic Potential of Isoflavones with an Emphasis on Daidzein. Oxidative Med Cell Longev. 2021 Sep 10;2021:6331630.1942-0900https://hdl.handle.net/20.500.13003/19873https://hdl.handle.net/20.500.12105/23222Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties.enghttp://creativecommons.org/licenses/by/4.0/Cardiovascular DiseasesOxidative StressIsoflavonesAnimalsHumansNeuroprotective AgentsNeoplasmsOsteoporosisSoybeansreview articleAttribution 4.0 International345399702021633163010.1155/2021/63316301942-0994Oxidative Medicine and Cellular Longevityopen accessAnimalesSojaHumanosNeoplasiasOsteoporosisEstrés OxidativoEnfermedades CardiovascularesIsoflavonasFármacos Neuroprotectores2-s2.0-85115813446697318600001L2014746679