Perez-Garcia, FelipeResino, SalvadorGómez-Sánchez, EstherGonzalo-Benito, HugoFernandez-Rodriguez, AmandaLorenzo-López, MarioHeredia-Rodríguez, MaríaGómez-Pesquera, EstefaníaTamayo, EduardoJimenez-Sousa, Maria AngelesGroup of Biomedical Research in Critical Care Medicine (BioCritic)2024-05-222024-05-222021-04Eur J Clin Invest. 2021 Apr;51(4):e13416.http://hdl.handle.net/20.500.12105/19520Background: Higher expression of olfactomedin-4 (OLFM4), a gene regulated by nuclear factor-kappa B (NF-κB), has been related to a higher risk of organ failure and death in patients with septic shock. We aimed to evaluate the association between OLFM4 single nucleotide polymorphisms (SNPs) and septic shock-related death in 175 patients who underwent major surgery, as well as its performance in predicting mortality. Materials and methods: We carried out a retrospective study. A total of seven OLFM4 SNPs were genotyped by Agena Bioscience's MassARRAY platform. Statistical analysis was performed by Kaplan-Meier and Cox regression tests. The diagnostic performance for predicting septic shock-related death was evaluated by the area under the receiver-operating characteristic (AUROC) curve. Results: Patients with rs17552047 A allele and rs1891944 TT genotype had higher survival than patients with rs17552047 G allele (P-value = .024) and patients with rs1891944 CC/CT genotype (P-value = .038). However, only rs17552047 was associated with a lower risk of death under an additive inheritance model (adjusted hazard ratio [aHR] = 0.44, 95% CI = 0.27-0.71). The multivariate model with the most significant clinical variables (lactate, chronic kidney disease, peritonitis, heart disease and elective surgery) showed an AUROC of 0.776 for predicting septic shock-related death. When we added the OLFM4 rs17552047 SNP to the previous model, the AUROC was 0.811 and was close to reaching significant differences with the previous model (P-value = .065). Conclusion: OLFM4 rs17552047 A allele predicts septic shock survival in patients who underwent major surgery. Furthermore, rs17552047, together with clinical variables, could be useful to predict the outcome of septic shock.engSMURhttp://creativecommons.org/licenses/by-nc-nd/4.0/Major surgeryOLFM4rs17552047Septic shockSNPsSurvivalAgedAttribution-NonCommercial-NoDerivatives 4.0 Internacional32996122514e1341610.1111/eci.134161365-2362European journal of clinical investigationopen access