Abas, SoniaRodriguez-Arevalo, SergioBagan, AndreaGrinan-Ferre, ChristianVasilopoulou, FoteiniBrocos-Mosquera, IriaMuguruza, CarolinaPerez, BelenMolins, EliesJavier Luque, FPerez-Lozano, Pilarde Jonghe, StevenDaelemans, DirkNaesens, LieveBrea, JoseIsabel Loza, MHernández-Hernández, ElenaGarcia-Sevilla, Jesus AJulia Garcia-Fuster, MRadan, MilicaDjikic, TeodoraNikolic, KatarinaPallas, MerceCallado, Luis FEscolano, Carmen2024-09-132024-09-132020-04-09Abas Sonia, Rodriguez-Arevalo Sergio, Bagan Andrea, Grinan-Ferre Christian, Vasilopoulou Foteini, Brocos-Mosquera Iria, et al. Bicyclic alpha-Iminophosphonates as High Affinity Imidazoline I-2 Receptor Ligands for Alzheimer's Disease. J Med Chem. 2020 Apr 09;63(7):3610-3633. Epub 2020 Mar 19.0022-2623http://hdl.handle.net/20.500.13003/11009https://hdl.handle.net/20.500.12105/22847Imidazoline I-2 receptors (I-2-IR), widely distributed in the CNS and altered in patients that suffer from neurodegenerative disorders, are orphans from a structural point of view, and new I-2-IR ligands are urgently required for improving their pharmacological characterization. We report the synthesis and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies of a new family of bicyclic alpha-iminophosphonates endowed with relevant affinities for human brain I-2-IR. Acute treatment in mice with a selected compound significantly decreased Fas-associated protein with death domain (FADD) in the hippocampus, a key signaling mediator of neuroprotective actions. Additionally, in vivo studies in the familial Alzheimer's disease 5xFAD murine model revealed beneficial effects in behavior and cognition. These results are supported by changes in molecular pathways related to cognitive decline and Alzheimer's disease. Therefore, bicyclic alpha-iminophosphonates are tools that may open new therapeutic avenues for I-2-IR, particularly for unmet neurodegenerative conditions.engSMURhttp://creativecommons.org/licenses/by-nc-nd/4.0/Alzheimer DiseaseMolecular StructureOrganophosphonatesQuantitative Structure-Activity RelationshipHippocampusHumansVero CellsChlorocebus aethiopsHeLa CellsCycloaddition ReactionMadin Darby Canine Kidney CellsLigandsDogsFemaleAnimalsImidazolesNootropic AgentsImidazoline ReceptorsMiceAttribution-NonCommercial-NoDerivatives 4.0 International321504146373610-363310.1021/acs.jmedchem.9b020801520-4804Journal of Medicinal Chemistryopen accessAnimalesImidazolesNootrópicosOrganofosfonatosCélulas de Riñón Canino Madin DarbyReacción de CicloadiciónFemeninoLigandosPerrosCélulas VeroCélulas HeLaReceptores de ImidazolinaRelación Estructura-Actividad CuantitativaHumanosHipocampoChlorocebus aethiopsEnfermedad de AlzheimerRatonesEstructura Molecular2-s2.0-85083077827526405300015L2005687973