Domínguez, FCuenca, SBilinska, ZToro, RVillard, EBarriales-Villa, ROchoa, JPAsselbergs, FSammani, AFranaszczyk, MAkhtar, MCoronado-Albi, MJRangel-Sousa, DRodriguez-Palomares, JFJiménez-Jáimez, JGarcia-Pinilla, JMRipoll-Vera, TMogollón-Jiménez, MVFontalba-Romero, AGarcia-Medina, DPalomino-Doza, Jde Gonzalo-Calvo, DCicerchia, MSalazar-Mendiguchia, JSalas, CPankuweit, SHey, TMMogensen, JBarton, PJCharron, PElliott, PGarcia-Pavia, P2026-02-242026-02-242018-11-13J Am Coll Cardiol. 2018 Nov 13;72(20):2471-2481.https://hdl.handle.net/20.500.12105/27265This work was supported by grants from the following institutions: Instituto de Salud Carlos III (ISCIII) (PI14/0967, PI15/01551, AC16/0014), CIBERCV (CB16/11/00403), Progreso and Salud Foundation (Junta de Andalucia) (PI-0011/201), Ministry of Economy, Industry and Competitiveness (IJCI-2016-29393), Mutual Medical (Research Award 2017), ERA-CVD Joint Transnational Call 2016 (Genprovic), British Heart Foundation (SP/10/10/28431), Wellcome Trust (107469/Z/15/), NIHR Royal Brompton Cardiovascular Biomedical Research Unit, NIHR Imperial Biomedical Research Center, Health Innovation Challenge Fund award from the Wellcome Trust and Department of Health, U.K. (HICF-R6-373), Danish Heart Foundation (16-R107-A6617), University of Southern Denmark, the Region of Southern Denmark, Odense University Hospital, German Competence Network Heart Failure, (TP9, FKZ 01GI0205), DETECTIN-HF project (ERA-CVD framework), and PROMEX Charitable Foundation. UCL Hospitals NIHR Biomedical Research Center and Netherlands Cardiovascular Research Initiative, an initiative with support of the Dutch Heart Foundation, CVON2015-12 eDETECT and CVON2014-40 DOSIS. The CNIC is supported by the Ministry of Economy, Industry and Competitiveness and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Grants from ISCIII and the Spanish Ministry of Economy and Competitiveness are supported by the Plan Estatal de IþDþI 2013-2016 – European Regional Development Fund (FEDER) “A way of making Europe.” The Hospital Universitario Puerta de Hierro Majadahonda, Hôpital PitiéSalpêtrière, and Saint Bartholomews’ Hospital are members of the European Reference Network for rare, low-prevalence, and complex diseases of the heart (ERN GUARD-Heart). Drs. Ochoa, Cicerchia, and Salazar-Mendiguchia are employees of Health In Code. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.engVoRhttp://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 InternationalJournal of the American College of Cardiologyopen access