Zapata-Wainberg, GQuintas, SXimenez-Carrillo Rico, ABenavente Fernandez, LMasjuan Vallejo, JGallego Cullere, JaimeFreijo Guerrero, Maria del MarEgido, JoseGomez Sanchez, JCMartinez Domeno, APurroy, FVives Pastor, BarbaraRodriguez Yanez, MVivancos, JGrp Investigadores Estudio TAC2024-09-062024-09-062018-09Zapata-Wainberg G, Quintas S, Ximenez-Carrillo Rico A, Benavente Fernandez L, Masjuan Vallejo J, Gallego Cullere J, et al. Prognostic factors and analysis of mortality due to brain haemorrhages associated with vitamin K antagonist oral anticoagulants. Results from the TAC registry. Neurologia. 2018 Sep;33(7):419-26. Epub 2016 Sep 16.0213-4853http://hdl.handle.net/20.500.13003/17449https://hdl.handle.net/20.500.12105/22629Introduction: Intracranial haemorrhages (ICH) represent a severe and frequently lethal complication in patients treated with vitamin K antagonists (VKA). The purpose of our study is to describe the factors and clinical features associated with mortality in these patients. Methods: We conducted an observational, retrospective, multi-centre study based on prospective stroke registries in Spain. We included all patients admitted to neurology departments during a one-year period who met the following inclusion criteria: being 18 or older, having a diagnosis of ICH, and receiving VKA. Clinical and radiological parameters and 3-month outcomes were analysed. Results: A total of 235 patients from 21 hospitals were included. Mortality rate at 90 days was 42.6%. Bivariate analysis showed a significant association between death and the following factors: median NIHSS score at admission (5 [IQR = 9] vs 17 [IQR = 14] points, P < .01) and presence of an extensive hemispheric haemorrhage (4.9% vs 35%, P < .01; chi(2)). Extensive hemispheric haemorrhages, in addition to being the most lethal type, were associated with a shorter time to death (mean of 16.5 days; 95% CI: 7.1-26). A logistic regression model showed that only baseline NIHSS scores independently predicted death (odds ratio =1.13 [95% CI: 1.08-1.17] for each point in the scale). Conclusion: ICH in patients treated with VKA is associated with high mortality rates; mortality in these patients is mainly and independently associated with the clinical situation at stroke onset.spahttp://creativecommons.org/licenses/by-nc-nd/4.0/Intracranial haemorrhageOral anticoagulantsAcenocoumarolWarfarinMortalityresearch articleAttribution-NonCommercial-NoDerivatives 4.0 International27645776337419-42610.1016/j.nrl.2016.07.0051578-1968Neurologiaopen accessAccidente CerebrovascularFemeninoVitamina KHemorragia CerebralHumanosPersona de Mediana EdadAdulto JovenCausas de MuertePronósticoAncianoAnciano de 80 o más AñosEstudios RetrospectivosAdultoAnticoagulantesEspañaSistema de Registros2-s2.0-84994772128444418800001L613216120