Aldámiz-Echevarria, TeresaBerenguer, JuanMiralles, PilarJimenez-Sousa, Maria AngelesCarrero, AnaPineda-Tenor, DanielDíez, CristinaTejerina, FranciscoPérez-Latorre, LeireBellón, José MaríaResino, Salvador2018-03-062018-03-062016-02-05PLoS One. 2016; 11(2): e0148537http://hdl.handle.net/20.500.12105/5668BACKGROUND: Higher serum levels of adhesion molecules (sICAM-1 and sVCAM-1) are associated with advanced liver fibrosis in patients coinfected with human immunodeficiency virus and hepatitis C virus. We assessed the relationship between serum levels of adhesion molecules and liver-related events (LRE) or death, in coinfected patients. METHODS: We studied clinical characteristics and outcomes of 182 coinfected patients with a baseline liver biopsy (58 with advanced fibrosis) and simultaneous plasma samples who were followed for median of 9 years. We used receiver-operating characteristic (ROC) curves to calculate optimized cutoff values (OCV) of sICAM-1 and sVCAM-1, defined as the values with the highest combination of sensitivity and specificity for LRE. We used multivariate regression analysis to test the association between OCVs of sICAM-1 and sVCAM-1 and outcomes. The variables for adjustment were age, HIV transmission category, liver fibrosis, baseline CD4+ T-cell counts, antiretroviral therapy, and sustained virologic response (SVR). RESULTS: During the study period 51 patients had SVR, 19 had LRE, and 16 died. The OCVs for LRE were 5.68 Log pg/mL for sICAM-1 and 6.25 Log pg/mL for sVCAM-1, respectively. The adjusted subhazard ratio (aSHR) (95% confidence interval [CI]) of death or LRE, whichever occurred first, for sICAM-1 and sVCAM-1 > OCV were 3.98 ([1.14; 13.89], P = 0.030) and 2.81 ([1.10; 7.19], respectively (P = 0.030). CONCLUSIONS: Serum levels of sICAM-1 and sVCAM-1 can serve as markers of outcome in HIV/HCV-coinfected patients. Therapies targeting necroinflammatory damage and fibrogenesis may have a role in the management chronic hepatitis C.engVoRhttp://creativecommons.org/licenses/by-nc-sa/4.0/AdultBiomarkersCD4-Positive T-LymphocytesCoinfectionFemaleFollow-Up StudiesHIV InfectionsHepatitis CHumansIntercellular Adhesion Molecule-1Kaplan-Meier EstimateLiver CirrhosisMaleRetrospective StudiesVascular Cell Adhesion Molecule-1Atribución-NoComercial-CompartirIgual 4.0 Internacional26849641112e014853710.1371/journal.pone.01485371932-6203PloS oneopen access