Benschop, Kimberley SMBroberg, Eeva KHodcroft, EmmaSchmitz, DennisAlbert, JanBaicus, AndaBailly, Jean-LucBaldvinsdottir, GudrunBerginc, NatasaBlomqvist, SoileBöttcher, SindyBrytting, MiaBujaki, ErikaCabrerizo, MariaCelma, CristinaCinek, OndrejClaas, Eric C JCremer, JeroenDean, JonathanDembinski, Jennifer LDemchyshyna, IrynaDiedrich, SabineDudman, SusanneDunning, JakeDyrdak, RobertEmmanouil, MaryFarkas, AgnesDe Gascun, CillianFournier, GuillaumeGeorgieva, IrinaGonzalez-Sanz, Rubenvan Hooydonk-Elving, JolandaJääskeläinen, Anne JJancauskaite, RutaKeeren, KathrinFischer, Thea KKrokstad, SidselNikolaeva-Glomb, LubomiraNovakova, LudmilaMidgley, Sofie ElisabethMirand, AudreyMolenkamp, RichardMorley, UrsulaMossong, JoëlMuralyte, SvajuneMurk, Jean-LucNguyen, TrungNordbø, Svein AÖsterback, RiikkaPas, SuzanPellegrinelli, LauraPogka, VassilikiProchazka, BirgitRainetova, PetraVan Ranst, MarcRoorda, LieuweSchuffenecker, IsabelleSchuurman, RobStoyanova, AsyaTempleton, KateVerweij, Jaco JVoulgari-Kokota, AndronikiVuorinen, TyttiWollants, ElkeWolthers, Katja CZakikhany, KatherinaNeher, RichardHarvala, HeliSimmonds, Peter2022-07-202022-07-202021-06Emerg Infect Dis. 2021 Jun;27(6):1616-1626.http://hdl.handle.net/20.500.12105/14756In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected persons 0-4 years of age (29%) and 25-34 years of age (27%). Sequences were divided into 6 genetic clades (G1-G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections.engVoRhttps://creativecommons.org/licenses/by/4.0/EuropeEuropean Non-Polio Enterovirus NetworkMolecular epidemiologyNextstrain; echovirus 30EnterovirusEpidemiological monitoringEvolutionary trajectoryGenetic recombinationMeningitis/encephalitisNeurological manifestationsVirusesWhole-genome sequencingEchovirus InfectionsEnterovirus InfectionsEnterovirus B, HumanEuropeGenotypeHumansMolecular EpidemiologyPhylogenySequence Analysis, DNAAtribución 4.0 Internacional340138742761616-162610.3201/eid2706.2030961080-6059Emerging Infectious Diseasesopen access