Lassale, CamilleGunter, Marc JRomaguera, DoraPeelen, Linda MVan der Schouw, Yvonne TBeulens, Joline WJFreisling, HeinzMuller, David CFerrari, PietroHuybrechts, IngeFagherazzi, GuyBoutron-Ruault, Marie-ChristineAffret, AurelieOvervad, KimDahm, Christina CatherineOlsen, AnjaRoswall, NinaTsilidis, Konstantinos KKatzke, Verena AKuehn, TilmanBuijsse, BrianQuiros, Jose-RamonSanchez-Cantalejo, EmilioEtxezarreta, NereaHuerta, José MaríaBarricarte, AurelioBonet, CatalinaKhaw, Kay-TeeKey, Timothy JTrichopoulou, AntoniaBamia, ChristinaLagiou, PagonaPalli, DomenicoAgnoli, ClaudiaTumino, RosarioFasanelli, FrancescaPanico, SalvatoreBueno-de-Mesquita, H. BasBoer, Jolanda M. ASonestedt, EmilyNilsson, Lena MariaRenstrom, FridaWeiderpass, ElisabeteSkeie, GuriLund, EilivMoons, Karel G. MRiboli, ElioTzoulaki, Ioanna2024-07-092024-07-092016-07-13Lassale C, Gunter MJ, Romaguera D, Peelen LM, Van Der Schouw YT, Beulens Joline WJ, et al. Diet Quality Scores and Prediction of All-Cause, Cardiovascular and Cancer Mortality in a Pan-European Cohort Study. PLoS One. 2016 Jul 13;11(7):e0159025.1932-6203http://hdl.handle.net/20.500.13003/10278http://hdl.handle.net/20.500.12105/20274Scores of overall diet quality have received increasing attention in relation to disease aetiology; however, their value in risk prediction has been little examined. The objective was to assess and compare the association and predictive performance of 10 diet quality scores on 10-year risk of all-cause, CVD and cancer mortality in 451,256 healthy participants to the European Prospective Investigation into Cancer and Nutrition, followed-up for a median of 12.8y. All dietary scores studied showed significant inverse associations with all outcomes. The range of HRs (95% CI) in the top vs. lowest quartile of dietary scores in a composite model including non-invasive factors (age, sex, smoking, body mass index, education, physical activity and study centre) was 0.75 (0.72-0.79) to 0.88 (0.84-0.92) for all-cause, 0.76 (0.69-0.83) to 0.84 (0.76-0.92) for CVD and 0.78 (0.73-0.83) to 0.91 (0.85-0.97) for cancer mortality. Models with dietary scores alone showed low discrimination, but composite models also including age, sex and other non-invasive factors showed good discrimination and calibration, which varied little between different diet scores examined. Mean C-statistic of full models was 0.73, 0.80 and 0.71 for all-cause, CVD and cancer mortality. Dietary scores have poor predictive performance for 10-year mortality risk when used in isolation but display good predictive ability in combination with other non-invasive common risk factors.enghttp://creativecommons.org/licenses/by/4.0/Cardiovascular DiseasesEuropean Continental Ancestry GroupHumansLife StyleMiddle AgedNeoplasmsDietMaleFemaleRisk FactorsAge DistributionSex DistributionCohort Studiesresearch articleAttribution 4.0 International27409582117e015902510.1371/journal.pone.0159025PloS Oneopen accessDistribución por EdadEstudios de CohortesDistribución por SexoFemeninoDietaGrupo de Ascendencia Continental EuropeaMasculinoFactores de RiesgoHumanosPersona de Mediana EdadNeoplasiasEstilo de VidaEnfermedades Cardiovasculares2-s2.0-84978771288379508300050L611245413