Lopez, AurelioMateos, Maria-VictoriaOriol, AlbertValero, MartaMartinez, JoaquinLorenzo, Jose IgnacioPerez, MontserratMartinez, Rafaelde Paz, RaquelGranell, Miguelde Arriba, FelipeBlanchard, M JesusPenalver, Francisco-JavierBello, Jose LuisMartin, Maria LuisaBargay Lleonart, JoanBlade, JoanLahuerta, Juan JoseSan Miguel, Jesus Fde la Rubia Comos, Javier2024-07-042024-07-042015Lopez A, Mateos MV, Oriol A, Valero M, Martinez J, Lorenzo JI, et al. Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations.. Leuk Res Rep. 2015;4(2):64-9.2213-0489http://hdl.handle.net/20.500.13003/17426http://hdl.handle.net/20.500.12105/20083We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P=0.037), in patients achieving CR (28.3 vs. 14.8 months; P=0.04), and in patients without aggressive relapse (28.6 vs. 7.6 months; P=0.0007).enghttp://creativecommons.org/licenses/by-nc-nd/4.0/Elderly patientsPatterns of relapseRelapsed myelomaresearch articleAttribution-NonCommercial-NoDerivatives 4.0 International265008504264-910.1016/j.lrr.2015.09.002Leukemia Research Reportsopen access2-s2.0-84942514302L606143667