Wangüemert-Pérez, J. GonzaloHadij-ElHouati, AbdelfettahSánchez-Postigo, AlejandroLeuermann, JonasXu, Dan-XiaCheben, PavelOrtega-Moñux, AlejandroHalir, RobertMolina-Fernández, Íñigo2024-02-082024-02-082018-08-230030-3992http://hdl.handle.net/10668/3343http://hdl.handle.net/20.500.12105/17620Silicon photonic biosensors hold the potential for highly accurate, yet low cost point-of-care devices. Maximizing the sensitivity of the sensing chips while reducing the complexity and cost of the read-out system is pivotal to realize this potential. Here we present an extensive analysis, both from a practical and a theoretical perspective, of current biosensors, and analyze how subwavelength structures can be exploited to enhance their sensitivity. This study is not restricted just to the near-infrared band as we also determine the sensing capabilities of the suspended silicon waveguides with subwavelength metamaterial cladding working in the mid-infrared range. These waveguides have been recently proposed to cover the full transparency window of silicon (λ < 8.5 μm), where the fingerprint spectral region of many molecules takes place and so a plethora of evanescent field absorption-based applications will be developed in the near future.engVoRhttps://creativecommons.org/licenses/by-nc-nd/4.0/Subwavelength waveguidesSilicon photonicsBiosensorsCoherent multi-port sensing architectureBiosensing TechniquesSiliconPoint-of-Care SystemsPhotonsPigmentation DisordersSkin AbnormalitiesAttribution-NonCommercial-NoDerivs 4.0 International10.1016/j.optlastec.2018.07.071Optics and Laser Technologyopen access