Castelpietra, GiulioSkrindo Knudsen, Ann KristinAgardh, Emilie EArmocida, BenedettaBeghi, MassimilianoMoesgaard Iburg, KimLogroscino, GiancarloMa, RuiStarace, FabrizioSteel, NicholasAddolorato, GiovanniAndrei, Catalina LilianaAndrei, TudorelAyuso-Mateos, José LuisBanach, MaciejBärnighausen, Till WinfriedBarone-Adesi, FrancescoSrikanth Bhagavathula, AkshayaCarvalho, FélixCarvalho, MárciaSingh Chandan, JohtKumar Chattu, VijayCouto, Rosa A SCruz-Martins, NatáliaDargan, Paul IDeuba, KeshabDias-da-Silva, DianaFagbamigbe, Adeniyi FrancisFernandes, EduardaFerrara, PietroFischer, FlorianAndras Gaal, PeterGialluisi, AlessandroHaagsma, Juanita AHaro, Josep MariaHasan, M TasdikHasan, Syed ShahzadHostiuc, SorinIacoviello, LiciaIavicoli, IvoJamshidi, ElhamJonas, Jost BJoo, TamasJozwiak, Jacek JerzyKatikireddi, Srinivasa VittalKauppila, Joonas HKhan, Moien A BKisa, AdnanKisa, SezerKivimäki, MikaKoly, Kamrun NaharKoyanagi, AiKumar, ManasiLallukka, TeaLangguth, BertholdLedda, CaterinaLee, Paul HLega, IlariaLinehan, ChristineLoureiro, Joana AMadureira-Carvalho, Áurea MMartinez-Raga, JoseMathur, Manu RajMcGrath, John JMechili, Enkeleint AMentis, Alexios-Fotios AMestrovic, TomislavMiazgowski, BartoszMirica, AndreeaMirijello, AntonioMoazen, BabakMohammed, ShafiuMulita, FranceskNagel, GabrieleNegoi, IonutNegoi, Ruxandra IrinaEbuka Nwatah, VincentPadron-Monedero, AliciaPanda-Jonas, SonghomitraPardhan, ShahinaPasovic, MajaPatel, JayPetcu, Ionela-RoxanaPinheiro, MarinaPollok, Richard Charles GPostma, Maarten JLaith Rawaf, DavidRawaf, SalmanRomero-Rodríguez, EsperanzaRonfani, LucaSagoe, DominicSanmarchi, FrancescoSchaub, Michael PTadesse Sharew, NigussieShiri, RahmanShokraneh, FarhadSigfusdottir, Inga DoraSilva, João PedroSilva, RenataSocea, BogdanSzócska, MiklósTabarés-Seisdedos, RafaelTorrado, MarcoTovani-Palone, Marcos RobertoVasankari, Tommi JuhaniVeroux, MassimilianoViner, Russell MWerdecker, AndreaWinkler, Andrea SylviaHay, Simon IFerrari, Alize JNaghavi, MohsenAllebeck, PeterMonasta, Lorenzo2023-02-272023-02-272022-04-01Lancet Reg Health Eur 2022 Apr 1;16:100341.http://hdl.handle.net/20.500.12105/15547Background: Mental health is a public health issue for European young people, with great heterogeneity in resource allocation. Representative population-based studies are needed. The Global Burden of Disease (GBD) Study 2019 provides internationally comparable information on trends in the health status of populations and changes in the leading causes of disease burden over time. Methods: Prevalence, incidence, Years Lived with Disability (YLDs) and Years of Life Lost (YLLs) from mental disorders (MDs), substance use disorders (SUDs) and self-harm were estimated for young people aged 10-24 years in 31 European countries. Rates per 100,000 population, percentage changes in 1990-2019, 95% Uncertainty Intervals (UIs), and correlations with Sociodemographic Index (SDI), were estimated. Findings: In 2019, rates per 100,000 population were 16,983 (95% UI 12,823 - 21,630) for MDs, 3,891 (3,020 - 4,905) for SUDs, and 89·1 (63·8 - 123·1) for self-harm. In terms of disability, anxiety contributed to 647·3 (432-912·3) YLDs, while in terms of premature death, self-harm contributed to 319·6 (248·9-412·8) YLLs, per 100,000 population. Over the 30 years studied, YLDs increased in eating disorders (14·9%;9·4-20·1) and drug use disorders (16·9%;8·9-26·3), and decreased in idiopathic developmental intellectual disability (-29·1%;23·8-38·5). YLLs decreased in self-harm (-27·9%;38·3-18·7). Variations were found by sex, age-group and country. The burden of SUDs and self-harm was higher in countries with lower SDI, MDs were associated with SUDs. Interpretation: Mental health conditions represent an important burden among young people living in Europe. National policies should strengthen mental health, with a specific focus on young people.engVoRhttp://creativecommons.org/licenses/by/4.0/Young peopleMental healthMental disordersSelf-harmSubstance useEuropeAtribución 4.0 Internacional353924521610034110.1016/j.lanepe.2022.1003412666-7762The Lancet regional health. Europeopen access