Garcia-Arellano, AnaRamallal, RaulRuiz-Canela, MiguelSalas-Salvado, JordiCorella, DoloresShivappa, NitinSchroeder, HelmutHebert, James RRos, EmilioGomez-Garcia, EnriqueEstruch, RamonLapetra, JoseAros, FernandoFiol Sala, MiquelSerra-Majem, LluisPinto, XavierBabio, NancyGonzalez, Jose IFito, MontserratAlfredo Martinez, JMartinez-Gonzalez, Miguel APREDIMED Investigators2024-07-042024-07-042015-06Garcia-Arellano A, Ramallal R, Ruiz-Canela M, Salas-Salvado J, Corella D, Shivappa N, et al. Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study. Nutrients. 2015 Jun;7(6):4124-38.http://hdl.handle.net/20.500.13003/10832http://hdl.handle.net/20.500.12105/20122Previous studies have reported an association between a more pro-inflammatory diet profile and various chronic metabolic diseases. The Dietary Inflammatory Index (DII) was used to assess the inflammatory potential of nutrients and foods in the context of a dietary pattern. We prospectively examined the association between the DII and the incidence of cardiovascular disease (CVD: myocardial infarction, stroke or cardiovascular death) in the PREDIMED (Prevencion con Dieta Mediterranea) study including 7216 high-risk participants. The DII was computed based on a validated 137-item food frequency questionnaire. Multivariate-adjusted hazard ratios (HR) and 95% confidence intervals of CVD risk were computed across quartiles of the DII where the lowest (most anti-inflammatory) quartile is the referent. Risk increased across the quartiles (i.e., with increasing inflammatory potential): HRquartile2 = 1.42 (95%CI = 0.97-2.09); HRquartile3 = 1.85 (1.27-2.71); and HRquartile4 = 1.73 (1.15-2.60). When fit as continuous the multiple-adjusted hazard ratio for each additional standard deviation of the DII was 1.22 (1.06-1.40). Our results provide direct prospective evidence that a pro-inflammatory diet is associated with a higher risk of cardiovascular clinical events.enghttp://creativecommons.org/licenses/by/4.0/Dietary inflammatory indexCardiovascular diseasePREDIMEDInflammationCardiovascular Diseasesresearch articleAttribution 4.0 International26035241764124-413810.3390/nu70641242072-6643Nutrientsopen accessÍndice de Masa CorporalDieta MediterráneaIncidenciaModelos de Riesgos ProporcionalesResultado del TratamientoFemeninoAnálisis MultivarianteAceite de OlivaMasculinoDeterminación de Punto FinalEstudios de SeguimientoFactores de RiesgoHumanosPersona de Mediana EdadNuecesIngestión de EnergíaEstudios ProspectivosInflamaciónAncianoAnciano de 80 o más AñosEncuestas y CuestionariosEnfermedades Cardiovasculares2-s2.0-85018224708357281800010L604764910