Sepulveda-Crespo, DanielJimenez-Sousa, Maria AngelesFernandez-Rodriguez, AmandaMuñoz-Fernández, María AJiménez, José LCaraciolo, Begoña BReus Bañuls, SergioVilchez, HelemMothe, BeatrizMartinez, IsidoroBenito, José MRallón, NormaResino, Salvador2026-06-112026-06-112023-11Sepúlveda-Crespo D, Jiménez-Sousa MA, Fernández-Rodíguez A, et al. IL7RA rs10491434 polymorphism is related to spontaneous HIV infection control in naïve HIV-infected patients: a retrospective study. J Med Virol. 2023;95:e29214. doi:10.1002/jmv.29214https://hdl.handle.net/20.500.12105/27528Interleukin 7 receptor (IL7R) is vital in the adaptive immune response against human immunodeficiency viruses (HIV). We assessed IL7RA polymorphisms (SNPs) in antiretroviral therapy (ART)-naïve HIV patients for their association with spontaneous HIV infection control. We conducted a retrospective cohort study involving 667 ART-naïve patients categorized by HIV progression (ordinal variable): 150 rapid progressors, 334 moderate/typical progressors, 86 long-term nonprogressors elite controllers (LTNPs-EC), and 97 LTNPs-non-EC. We genotyped three IL7RA SNPs using Agena Bioscience's MassARRAY platform. The association between IL7RA SNPs and spontaneous HIV infection control was evaluated using ordinal logistic regression. Individuals carrying the rs10491434 G allele have a higher likelihood of spontaneous HIV infection control (adjusted odds ratio [aOR] = 1.33; p = 0.023). Moreover, the IL7RA GCT haplotype, consisting of three specific SNPs (rs6897932, rs987106, and rs10491434), demonstrated an association with the control of untreated HIV infection (aOR = 1.34; p = 0.050). Remarkably, the rs10491434 SNP and the IL7RA GCT haplotype exhibited similar aOR values, suggesting that rs10491434 may be primarily responsible for the observed effect of the haplotype. IL7RA rs10491434 G allele is associated with a higher likelihood of spontaneous HIV infection control, indicating its significant role in the pathogenesis of HIV, possibly influencing infection course and viral replication control.engAMhttp://creativecommons.org/licenses/by-nc-nd/4.0/HIV elite controllersIL7 receptorLTNPsSingle nucleotide polymorphismsDisease ProgressionHIV InfectionsHumansInfection ControlInterleukin-7 Receptor alpha SubunitPolymorphism, Single NucleotideRetrospective StudiesAttribution-NonCommercial-NoDerivatives 4.0 International379271089511e2921410.1002/jmv.29214Journal of Medical Virologyopen access