Vicent, LourdesÁlvarez-García, JesúsVazquez-Garcia, RafaelGonzález-Juanatey, José RRivera, MiguelSegovia, JavierPascual-Figal, Domingo ABover, RamónWorner, FernandoFernández-Avilés, FranciscoAriza-Sole, AlbertMartínez-Sellés, Manuel2023-07-172023-07-172023-04-21J Clin Med. 2023 Apr 21;12(8):30282077-0383http://hdl.handle.net/20.500.12105/16254Our aim was to determine the prognostic impact of coronary artery disease (CAD) on heart failure with reduced ejection fraction (HFrEF) mortality and readmissions. From a prospective multicenter registry that included 1831 patients hospitalized due to heart failure, 583 had a left ventricular ejection fraction of <40%. In total, 266 patients (45.6%) had coronary artery disease as main etiology and 137 (23.5%) had idiopathic dilated cardiomyopathy (DCM), and they are the focus of this study. Significant differences were found in Charlson index (CAD 4.4 ± 2.8, idiopathic DCM 2.9 ± 2.4, p < 0.001), and in the number of previous hospitalizations (1.1 ± 1, 0.8 ± 1.2, respectively, p = 0.015). One-year mortality was similar in the two groups: idiopathic DCM (hazard ratio [HR] = 1), CAD (HR 1.50; 95% CI 0.83-2.70, p = 0.182). Mortality/readmissions were also comparable: CAD (HR 0.96; 95% CI 0.64-1.41, p = 0.81). Patients with idiopathic DCM had a higher probability of receiving a heart transplant than those with CAD (HR 4.6; 95% CI 1.4-13.4, p = 0.012). The prognosis of HFrEF is similar in patients with CAD etiology and in those with idiopathic DCM. Patients with idiopathic DCM were more prone to receive heart transplant.engVoRhttp://creativecommons.org/licenses/by/4.0/Atribución 4.0 Internacional3710936512810.3390/jcm12083028Journal of clinical medicineopen access