Hidalgo-Chicharro, AlbertoAbad, RaquelNavarro-Marí, José MaríaGutiérrez-Fernández, José2022-04-082022-04-082017JMM Case Rep. 2017;4(10):e005121.2053-3721http://hdl.handle.net/20.500.12105/13971Introduction. Preterm premature rupture of membranes (PPROM) usually has a multifactorial etiology that is often unknown, although the most frequently reported cause is infection by group B Streptococcus. Therefore, the etiology of PPROM, although probably infectious, remains unknown in most cases. This case describes a PPROM caused by infection from oropharyngeal microbiota. Case presentation. We report the case of a 26-yr-old pregnant woman. The gestational age was 32 weeks+5 days. Examinations in the emergency department revealed the release of clear amniotic fluid and a closed multiparous cervix with a length of 22 mm. Endocervical culture evidenced the growth of Staphylococcus aureus, serogroup B Neisseria meningitidis and Haemophilus influenzae. Conclusion. Preventive antibiotic therapy should consider: opportunistic infections by normal genital microbiota, infections due to sexual activity, opportunist microorganisms derived from oral sex, and the hematogenous spread of oral bacteria.engVoRhttp://creativecommons.org/licenses/by/4.0/Haemophilus influenzaeNeisseria meningitidisStaphylococcus aureusMolecular characterizationPremature rupture of membranesPreventive antibiotic therapyAtribución 4.0 Internacional29188068410e00512110.1099/jmmcr.0.005121JMM Case Reportsopen access