Jimenez-Sousa, Maria AngelesGómez-Moreno, Ana ZaidaPineda-Tenor, DanielSánchez-Ruano, Juan JoséFernandez-Rodriguez, AmandaArtaza-Varasa, TomasGomez-Sanz, AliciaMartin-Vicente, MariaVázquez-Morón, SoniaResino, Salvador2024-05-222024-05-222018-06J Clin Virol. 2018 Jun:103:71-74.http://hdl.handle.net/20.500.12105/19517Background: Host genetic background has been associated with liver fibrosis progression. Objective: To analyze the association between the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism and liver fibrosis progression in hepatitis C virus (HCV)-infected patients. Study design: In this retrospective cohort study, 187 patients with chronic HCV infection were included, who had at least two liver stiffness measurements (LSM) by transient elastography during the follow-up. Results were expressed in kilopascals (kPa). The analysis of genetic association was carried out according to additive model by using Generalized Linear Models. Results: No patients had advanced fibrosis/cirrhosis at baseline. During a median follow-up time of 47.9 months, 15 patients developed advanced fibrosis and 17 cirrhosis. In multivariate analysis adjusted by the main clinical and epidemiological covariates, the rs738409 G allele was related to higher increase of LSM values during the follow-up (adjusted arithmetic mean ratio (aAMR) = 1.16 (95%CI = 1.04; 1.29); p = .006) and higher odds of having progression to advanced fibrosis [aOR = 2.03 (95%CI = 1.01; 4.06); p = .045], and progression to cirrhosis [aOR = 3.03 (95%CI = 1.26; 7.30); p = .014]. Conclusions: PNPLA3 rs738409 polymorphism appears to be related to the increased progression of liver fibrosis in HCV infected patients.engAMhttp://creativecommons.org/licenses/by-nc-nd/4.0/Chronic hepatitis CCirrhosisHepatic fibrosisLiver stiffnessPNPLA3SNPsDisease SusceptibilityPolymorphism, Single NucleotideAdultDisease ProgressionElasticity Imaging TechniquesFemaleGenetic Association StudiesHepatitis C, ChronicHumansLipaseLiverLiver CirrhosisLongitudinal StudiesMaleMembrane ProteinsMiddle AgedRetrospective StudiesAttribution-NonCommercial-NoDerivatives 4.0 Internacional2967418310371-7410.1016/j.jcv.2018.04.0081873-5967Journal of clinical virology : the official publication of the Pan American Society for Clinical Virologyopen access