Kapoor, Pooja MiddhaMavaddat, NasimChoudhury, Parichoy PalWilcox, Amber NLindström, SaraBehrens, SabineMichailidou, KyriakiDennis, JoeBolla, Manjeet KWang, QinJung, AudreyAbu-Ful, ZomorodaAhearn, ThomasAndrulis, Irene LAnton-Culver, HodaArndt, VolkerAronson, Kristan JAuer, Paul LFreeman, Laura E BeaneBecher, HeikoBeckmann, Matthias WBeeghly-Fadiel, AliciaBenitez, JavierBernstein, LeslieBojesen, Stig EBrauch, HiltrudBrenner, HermannBrüning, ThomasCai, QiuyinCampa, DanieleCanzian, FedericoCarracedo, ÁngelCarter, Brian DCastelao, Jose EChanock, Stephen JChatterjee, NilanjanChenevix-Trench, GeorgiaClarke, Christine LCouch, Fergus JCox, AngelaCross, Simon SCzene, KamilaDai, James YEarp, H SheltonEkici, Arif BEliassen, A HeatherEriksson, MikaelEvans, D GarethFasching, Peter AFigueroa, JonineFritschi, LinGabrielson, MarikeGago-Dominguez, ManuelaGao, ChiGapstur, Susan MGaudet, Mia MGiles, Graham GGonzález-Neira A, AnnaGuénel, PascalHaeberle, LotharHaiman, Christopher AHåkansson, NiclasHall, PerHamann, UteHatse, SigridHeyworth, JaneHolleczek, BerndHoover, Robert NHopper, John LHowell, AnthonyHunter, David JJohn, Esther MJones, Michael EKaaks, RudolfKeeman, RenskeKitahara, Cari MKo, Yon-DschunKoutros, StellaKurian, Allison WLambrechts, DietherMarchand, Loic LeLee, EunjungLejbkowicz, FlavioLinet, MarthaLissowska, JolantaLlaneza, AnaMacInnis, Robert JMartinez, Maria ElenaMaurer, TabeaMcLean, CatrionaNeuhausen, Susan LNewman, William GNorman, AaronO'Brien, Katie MOlshan, Andrew FOlson, Janet EOlsson, HåkanOrr, NickPerou, Charles MPita, GuillermoPolley, Eric CPrentice, Ross LRennert, GadRennert, Hedy SRuddy, Kathryn JSandler, Dale PSaunders, ChristobelSchoemaker, Minouk JSchöttker, BenSchumacher, FredrickScott, ChristopherScott, Rodney JShu, Xiao-OuSmeets, AnnSouthey, Melissa CSpinelli, John JStone, JenniferSwerdlow, Anthony JTamimi, Rulla MTaylor, Jack ATroester, Melissa AVachon, Celine Mvan Veen, Elke MWang, XiaoliangWeinberg, Clarice RWeltens, CarolineWillett, WalterWinham, Stacey JWolk, AlicjaYang, Xiaohong RZheng, WeiZiogas, ArgyriosDunning, Alison MPharoah, Paul D PSchmidt, Marjanka KKraft, PeterEaston, Douglas FMilne, Roger LGarcía-Closas, MontserratChang-Claude, Jenny2020-05-042020-05-042020-05-02J Natl Cancer Inst . 2020 ;djaa056.0027-8874http://hdl.handle.net/20.500.12105/9872We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history), and on average 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.engAMhttp://creativecommons.org/licenses/by-nc-sa/4.0/Breast cancerEpidemiologyGene-environment interactionsGenetic susceptibilityPolygenic risk scoreRisk factorsRisk predictionAtribución-NoComercial-CompartirIgual 4.0 Internacional3235915810.1093/jnci/djaa0561460-2105Journal of the National Cancer Instituteopen access