Lopez-Andrade, BernardoGutierrez, AntonioGarcia, LuciaCunill, VanesaDuran Pastor, Maria AntoniaSampol Mayol, AntoniaBernues, MartaIglesias, JulioRamos-Asensio, RafaelLlado, JosepSanchez, MariaCarlos Amat, JuanMartinez-Serra, Jordi2024-07-092024-07-092016-07-29Lopez-Andrade B, Sartori F, Gutierrez A, Garcia L, Cunill Monjo V, Duran Pastor MA, et al. Acute lymphoblastic leukemia with e1a3 BCR/ABL fusion protein. A report of two cases. Exp Hematol Oncol. 2016 Jul 29;5:21.http://hdl.handle.net/20.500.13003/10270http://hdl.handle.net/20.500.12105/20279B Acute Lymphoblastic leukemia (B-ALL) with Philadelphia chromosome (Ph') is a neoplasm of lymphoblast committed to the B cell lineage. The clinical presentation of B-ALL Ph'+ is similar to B-ALL, but is more common in adults than in children. The e1a3 rare variant is produced by the fusion of BCR exon 1 to ABL exon 3. The presence of this translocation has been associated with good disease outcome for chronic myeloid leukemia in a very small series of only 5 cases; there is no such evidence for B-ALL. We report two new cases of B-ALL Ph+ with the rare e1a3 fusion transcript. The e1a3 and e1a2 (p190) transcripts have been reported to have a similar molecular weight and probably a similar clinical profile, thus in these cases the presence of e1a3 was associated with extramedullary infiltration and disease acceleration.enghttp://creativecommons.org/licenses/by/4.0/research articleAttribution 4.0 International2747868452110.1186/s40164-016-0049-y2162-3619Experimental Hematology & Oncologyopen access2-s2.0-85006219363381118900001L611406479