Donat-Vargas, CarolinaGuerrero-Zotano, ÁngelCasas, Ana MaríaBaena-Cañada, José ManuelLope Carvajal, VirginiaAntolín, SilviaGarcía-Sáenz, José ÁngelBermejo, BegoñaMuñoz, MontserratRamos, Manuelde Juan, AnaJara Sánchez, CarlosSánchez-Rovira, PedroAntón, AntonioBrunet, JoanGavilá, JoaquínSalvador, JavierArriola-Arellano, EsperanzaBezares, SusanaFernandez de Larrea-Baz, NereaPerez-Gomez, BeatrizMartín, MiguelPollan-Santamaria, Marina2022-04-272022-04-272021-09-06Br J Cancer. 2021 Oct;125(8):1168-1176.http://hdl.handle.net/20.500.12105/14199Background: Wthere are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. Objective: To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). Methods: 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime. Results: Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (≥15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, ≥15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood. Conclusions: The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.engVoRhttp://creativecommons.org/licenses/by/4.0/Alcohol consumptionBreast cancerRisk factorAtribución 4.0 Internacional3448333812581168-117610.1038/s41416-021-01492-w1532-1827British Journal of Canceropen access