Castilla-Ortega, EstelaEscuredo, LeticiaBilbao, AinhoaPedraza, CarmenOrio, LauraEstivill-Torrús, GuillermoSantín, Luis JRodríguez de Fonseca, FernandoPavón, Francisco Javier2024-01-152024-01-152014-01-07http://hdl.handle.net/10668/1611http://hdl.handle.net/20.500.12105/17055The role of lysophosphatidic acid (LPA) in the control of emotional behavior remains to be determined. We analyzed the effects of the central administration of 1-oleoyl-LPA (LPA 18∶1) in rats tested for food consumption and anxiety-like and depression-like behaviors. For this purpose, the elevated plus-maze, open field, Y maze, forced swimming and food intake tests were performed. In addition, c-Fos expression in the dorsal periaqueductal gray matter (DPAG) was also determined. The results revealed that the administration of LPA 18∶1 reduced the time in the open arms of the elevated plus-maze and induced hypolocomotion in the open field, suggesting an anxiogenic-like phenotype. Interestingly, these effects were present following LPA 18∶1 infusion under conditions of novelty but not under habituation conditions. In the forced swimming test, the administration of LPA 18∶1 dose-dependently increased depression-like behavior, as evaluated according to immobility time. LPA treatment induced no effects on feeding. However, the immunohistochemical analysis revealed that LPA 18∶1 increased c-Fos expression in the DPAG. The abundant expression of the LPA1 receptor, one of the main targets for LPA 18∶1, was detected in this brain area, which participates in the control of emotional behavior, using immunocytochemistry. These findings indicate that LPA is a relevant transmitter potentially involved in normal and pathological emotional responses, including anxiety and depression.engVoRhttps://creativecommons.org/licenses/by/4.0/receptores de ácidos lisofosfatídicosConducta animalDepresiónRatasAnsiedadEvaluación nutricionalAprendizaje por laberintoNataciónInmunohistoquímicaReceptors, Lysophosphatidic AcidBehavior, AnimalDepressionRatsAnxietyNutrition AssessmentMaze LearningSwimmingImmunohistochemistryAttribution 4.0 International2440932710.1371/journal.pone.00853481932-6203PloS oneopen access