Gomez-Sanchez, LeticiaGarcia-Ortiz, LuisCarmen Patino-Alonso, MRecio-Rodriguez, Jose IRigo Carratala, FernandoMarti, RuthAgudo-Conde, CristinaRodriguez-Sanchez, EmilianoMaderuelo-Fernandez, Jose ARamos-Asensio, RafaelGomez-Marcos, Manuel AMARK Grp2024-07-092024-07-092016-10-24Gomez-Sanchez L, Garcia-Ortiz L, Patino-Alonso MC, Recio-Rodriguez JI, Rigo Carratala F, Marti R, et al. Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial. Cardiovasc Diabetol. 2016 Oct 24;15:148.1475-2840http://hdl.handle.net/20.500.13003/10118http://hdl.handle.net/20.500.12105/20292Background: The cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV) can reflect both central and peripheral arterial stiffness. Metabolic syndrome (MetS) and its components may increase arterial stiffness and the risk of cardiovascular diseases. However, the correlation of MetS and its components with arterial stiffness is still not clear. The primary aim of this study is thus the relationship using baPWV and CAVI in Caucasian adults with intermediate cardiovascular risk. The secondary aim is to analyze sex differences. Methods: This study analyzed 2351 subjects aged 35-74 years (mean, 61.4 +/- 7.7 years) comprising 61.7 % males and enrolled in the improving interMediAte Risk management (MARK) study. CAVI was measured using a VaSera VS-1500 (R) device, and baPWV was calculated using a validated equation. MetS was defined based on the Joint Scientific Statement National Cholesterol Education Program III. Waist circumference, blood pressure, fasting plasma glucose, and lipid profile were measured. Results: MetS was found in 51.9 % of the subjects. All MetS components except reduced HDL-cholesterol (p = 0.578) were associated with CAVI. High density lipoprotein cholesterol (p = 0.075) and waist circumference (p = 0.315) were associated with baPWV. The different MetS components that assess dyslipidemia using the stiffness measures show different associations according to patient sex. The high blood pressure component had a greater odds ratio (OR) for both baPWV >= 17.5 m/sec (OR = 6.90, 95 % CI 3.52-13.519) and CAVI >= 9 (OR = 2.20, 95 % CI 1.63-1.90). Conclusions: MetS and all its components (except HDL-cholesterol with baPWV and CAVI and WC with baPWV) were associated with baPWV and CAVI. However, there were sex differences in the association of MetS and its components with baPWV and CAVI. Data from this study suggest a greater association of CAVI and baPWV values with MetS components in males than in females and indicate greater arterial stiffness in the event of simultaneously elevated blood pressure, fasting plasma glucose, and waist circumference.enghttp://creativecommons.org/licenses/by/4.0/Metabolic syndromeBrachial-ankle pulse wave velocityCardio-ankle vascular indexArterial stiffnessAgedEuropean Continental Ancestry GroupHumansBlood PressureCross-Sectional StudiesPrognosisLipidsMaleMultivariate AnalysisBiomarkersPredictive Value of TestsChi-Square DistributionFemaleRisk FactorsCardiovascular DiseasesMetabolic SyndromeBlood GlucosePulse Wave AnalysisMiddle AgedSex FactorsVascular StiffnessOdds RatioAnkle Brachial IndexLinear ModelsWaist CircumferenceLogistic Modelsresearch articleAttribution 4.0 International277765261514810.1186/s12933-016-0465-7Cardiovascular Diabetologyopen accessModelos LinealesModelos LogísticosOportunidad RelativaFemeninoGrupo de Ascendencia Continental EuropeaLípidosMasculinoCircunferencia de la CinturaFactores SexualesÍndice Tobillo BraquialPersona de Mediana EdadGlucemiaRigidez VascularEnfermedades CardiovascularesAnálisis de la Onda del PulsoBiomarcadoresDistribución de Chi-CuadradoSíndrome MetabólicoAnálisis MultivarianteEstudios TransversalesFactores de RiesgoPresión SanguíneaHumanosValor Predictivo de las PruebasPronósticoAnciano2-s2.0-84992386138385976600001L612885984