Párraga, RocíoReal, CarlosGarcía-Lunar, InésPizarro, GonzaloSánchez-González, JavierDiaz-Munoz, RaquelGonzález-Calvo, ErnestoFernandez-Alvira, Juan MiguelMartínez-Gómez, JesúsFernández-Jiménez, Rodrigo2025-12-102025-12-102024-06J Cardiovasc Transl Res. 2024 Jun;17(3):554-557.https://hdl.handle.net/20.500.12105/27004This study aimed to evaluate the presence of subclinical myocardial damage in adolescents who were vaccinated against SARS-CoV-2. One hundred twenty asymptomatic adolescents with a mean age of 16.0 ± 0.4 years (51% girls) underwent cardiac magnetic resonance (CMR) imaging. SARS-CoV-2 IgG/IgM antibody testing was performed, and self-reported dates of confirmed SARS-CoV-2 infection and/or vaccination were collected. Participants were classified according to SARS-CoV-2 status as naïve (non-infected and unvaccinated, n = 74), infected (unvaccinated, n = 23), and vaccinated (independently of past infection status, n = 23). Biventricular volumes and ejection fraction and myocardial T2 relaxation time were similar in the three groups. T1 relaxation time was slightly higher in vaccinated adolescents (1249 ± 35 ms) than in naïve and infected participants (1231 ± 30 ms and 1227 ± 29 ms, respectively; p = 0.035), although this difference was considered clinically irrelevant. This observational study found no evidence of relevant subclinical myocardial involvement after SARS-CoV-2 vaccination in asymptomatic adolescents.The EnIGMA (Early ImaGing Markers of unhealthy lifestyles in Adolescents) study was funded by the Instituto de Salud Carlos III (ISCIII) through the project "PI19/01704" and co-funded by the European Union. CR is granted by the Fundacion Interhospitalaria para la Investigación Cardiovascular. J.M-G is a recipient of grant FPU21/04891 (Ayudas para la formación de profesorado universitario, FPU-2021) from the Ministerio de Educación, Cultura y Deporte. The CNIC is supported by the ISCIII, the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033).engAMhttp://creativecommons.org/licenses/by-nc-nd/4.0/AdolescentsCardiovascular magnetic resonanceMyocarditisSARS-CoV-2Attribution-NonCommercial-NoDerivatives 4.0 International38112908173554-557JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCHopen access