Palomo, IvánWehinger, SergioAndres, VicenteGarcía-García, Francisco JFuentes, Eduardo2024-07-022024-07-022024-04J Cell Mol Med. 2024 Apr;28(8):e18153.http://hdl.handle.net/20.500.12105/19918The small GTPase RhoA and the downstream Rho kinase (ROCK) regulate several cell functions and pathological processes in the vascular system that contribute to the age-dependent risk of cardiovascular disease, including endothelial dysfunction, excessive permeability, inflammation, impaired angiogenesis, abnormal vasoconstriction, decreased nitric oxide production and apoptosis. Frailty is a loss of physiological reserve and adaptive capacity with advanced age and is accompanied by a pro-inflammatory and pro-oxidative state that promotes vascular dysfunction and thrombosis. This review summarises the role of the RhoA/Rho kinase signalling pathway in endothelial dysfunction, the acquisition of the pro-thrombotic state and vascular ageing. We also discuss the possible role of RhoA/Rho kinase signalling as a promising therapeutic target for the prevention and treatment of age-related cardiovascular disease.engVoRhttp://creativecommons.org/licenses/by/4.0/Cardiovascular DiseasesThrombosisVascular DiseasesHumansrho-Associated KinasesEndothelial CellsAtribución 4.0 Internacional38568071288e1815310.1111/jcmm.181531582-4934Journal of cellular and molecular medicineopen access