Dierssen-Sotos, TrinidadPalazuelos-Calderón, CamiloJimenez-Moleon, Jose J.Aragones, NuriaAltzibar, Jone MCastaño-Vinyals, GemmaMartín-Sánchez, VicenteGómez-Acebo, InésGuevara, MarcelaTardón, AdoninaPerez-Gomez, BeatrizAmiano, PilarMoreno, VictorMolina, Antonio JAlonso-Molero, JéssicaMoreno-Iribas, ConchiKogevinas, ManolisPollan-Santamaria, MarinaLlorca, Javier2019-01-302019-01-302018-03-12BMC Cancer. 2018 Mar 12;18(1):280.1471-2407http://hdl.handle.net/20.500.12105/7022BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.engVoRhttps://creativecommons.org/licenses/by/4.0/Breast cancerGenetic interactionsReproductive factorsAdultAgedAllelesBasic-Leucine Zipper Transcription FactorsBreast NeoplasmsCyclic AMP Response Element-Binding ProteinFemaleGenetic Predisposition to DiseaseHormonesHumansAttribution 4.0 International2953000318128010.1186/s12885-018-4182-31471-2407BMC canceropen access