Carrión-García, Cayetano JavierGuerra-Hernández, Eduardo JesúsGarcía-Villanova, BelénSerafini, MauroSánchez, María-JoséAmiano, PilarMolina-Montes, Esther2024-06-122024-06-122020-04-05Antioxidants (Basel). 2020 ;9(4):3012076-3921http://hdl.handle.net/20.500.12105/19758Background: Little is known about the interlinkages between dietary and plasma non-enzymatic antioxidant capacity (D-NEAC and P-NEAC, respectively) and the body's antioxidant and inflammation response. Our aim was to explore these associations in 210 participants from two Spanish European Prospective Investigation into Cancer and Nutrition (EPIC) centers. Methods: D-NEAC was estimated using published NEAC values in food. P-NEAC and total polyphenols (TP) were quantified by FRAP (ferric-reducing antioxidant power), TRAP (total radical-trapping antioxidant parameter), TEAC-ABTS (trolox equivalent antioxidant capacity - Azino Bis Thiazoline Sulfonic), ORAC (oxygen radical absorbance capacity) and Folin-Ciocalteu assays. Nutrient antioxidants (carotenes, α-tocopherol, ascorbic acid, retinol, uric acid, Q9 and Q10 coenzymes) and inflammation markers (IL-6, IL-8, CRP, TNF-α, PAI-I, resistin and adiponectin) were also analyzed. Spearman correlation and linear regression analyses were performed in association analyses. Analyses were stratified by covariates and groups were defined using cluster analysis. Results: P-FRAP was correlated with D-NEAC, and significantly associated with P-NEAC in multivariate adjusted models. P-FRAP levels were also significantly associated with plasma antioxidants (log2 scale: TP β = 0.26; ascorbic acid β = 0.03; retinol β = 0.08; α-tocopherol β = 0.05; carotenes β = 0.02; Q10 β = 0.06; uric acid β = 0.25), though not with inflammation-related biomarkers. Different profiles of individuals with varying levels of P-NEAC and biomarkers were found. Conclusions: P-NEAC levels were to some extent associated with D-NEAC and plasma antioxidants, yet not associated with inflammation response.enghttp://creativecommons.org/licenses/by-nc-nd/4.0/otherAttribution-NonCommercial-NoDerivatives 4.0 Internacional322605179410.3390/antiox9040301Antioxidants (Basel, Switzerland)open access